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FNIP1 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS375229

MBS375229 is an antibody targeting FNIP1. Also known as Rabbit Anti-FNIP1. Reactive in Mouse, Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
FNIP1, Antibody
Full Product Name
Rabbit Anti-FNIP1
Product Gene Name
anti-FNIP1 antibody
Product Synonym Names
KIAA1961 antibody; FLCN-interacting protein antibody; FNIP1 antibody; Folliculin interacting protein 1 antibody
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
Unpurified antiserum containing 0.1% sodium azide;
Purity/Purification
Unpurified
Molecular Weight
127,444 Da
OMIM
610594
3D Structure
ModBase 3D Structure for Q8TF40
Target Antigen
FNIP1
Immunogen
A peptide at the N-terminus of FNIP1, MAPTLFQKLFSKRTGLGAC-amide
Research Areas
BirtHoggDub; Tumor suppressor
Applications Tested/Suitable for anti-FNIP1 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-FNIP1 antibody
Optimal antibody dilution should be determined by titration, however as a guideline try at WB: 1/1000 - 1/2000. Predicted molecular weight: 131 kDa.

Product References and Citations for anti-FNIP1 antibody

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling Masaya Baba et al (Proc Natl Acad Sci U S A,October 17 2006) PUBMED

Other Notes

Small volumes of anti-FNIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FNIP1. It may not necessarily be applicable to this product.

NCBI GI #
120953291
NCBI GeneID
96459
NCBI Accession #
NP_588613.2
UniProt Primary Accession #
Q8TF40
UniProt Secondary Accession #
Q86T47; Q9BUT0; D6RJH5
UniProt Related Accession #
Q8TF40
GenBank Nucleotide #
NM_133372.2
NCBI Official Full Name
folliculin-interacting protein 1 isoform 1
NCBI Official Synonym Full Names
folliculin interacting protein 1
NCBI Official Symbol
FNIP1
UniProt Protein Name
Folliculin-interacting protein 1
Protein Family
Folliculin-interacting protein
UniProt Gene Name
FNIP1
UniProt Synonym Gene Names
KIAA1961
UniProt Entry Name
FNIP1_HUMAN
NCBI Protein Information
folliculin-interacting protein 1

UniProt Comments for FNIP1

FNIP1: May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. Belongs to the FNIP family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 5q23.3

Cellular Component: cytoplasm

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity

Biological Process: regulation of protein amino acid phosphorylation; negative regulation of TOR signaling pathway; TOR signaling pathway; positive regulation of B cell apoptosis; immature B cell differentiation; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; cellular response to starvation; positive regulation of peptidyl-serine phosphorylation; positive regulation of GTPase activity
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Research Articles on FNIP1

1. The FLCN-FNIP complex deregulated in Birt-Hogg-Dube syndrome is absolutely required for B-cell differentiation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FNIP1 antibody

 Reference Product  PubMed Publications
 FLCN antibody  >14 publications with FNIP1 and FLCN
 SMCR8 antibody  >1 publications with FNIP1 and SMCR8

Diseases associated with anti-FNIP1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with FNIP1 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with FNIP1 and Disease Models, Animal
 Lung Diseases Antibodies  >1 publications with FNIP1 and Lung Diseases

Organs/Tissues associated with anti-FNIP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >6 publications with FNIP1 and Kidney
 Lung Antibodies  >3 publications with FNIP1 and Lung
 Blood Antibodies  >3 publications with FNIP1 and Blood
 Thymus Antibodies  >1 publications with FNIP1 and Thymus
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