SUN2 Antibody – Rabbit

SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]

SUN2: a nuclear transmembrane protein. Forms part of a membrane-spanning fibrillar complex that interconnects attached meiotic telomeres with cytoplasmic structures. Together with SUN1 connects the nuclear envelope with the centrosome. Interacts with RAB5A. Reportedly expressed in the endosome where it may play a role in endosome fusion and endocytosis.

Protein type: Nuclear envelope; Membrane protein, integral

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nuclear membrane; condensed nuclear chromosome; nuclear chromosome, telomeric region; integral to nuclear inner membrane; endosome membrane; nuclear envelope

Molecular Function: identical protein binding; protein binding; microtubule binding; lamin binding

Biological Process: mitotic spindle organization and biogenesis; centrosome localization; nuclear migration along microfilament; nuclear migration; nuclear membrane organization and biogenesis; positive regulation of cell migration