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Kallikrein 2 (KLK2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS375334

MBS375334 is an antibody targeting KLK2. Also known as Mouse Anti-Kallikrein 2 [6B7]: Horseradish Peroxidase (HRP). Reactive in Human. Host: Mouse. More details

$895 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Kallikrein 2 (KLK2), Monoclonal Antibody
Full Product Name
Mouse Anti-Kallikrein 2 [6B7]: Horseradish Peroxidase (HRP)
Product Gene Name
Product Synonym Names
Hk2; hK2 antibody; KLK2A 2 antibody; KLK2A2 antibody; Tissue kallikrein 2 antibody; Glandularkallikrein 2 antibody; hGK 1 antibody; Kallikrein 2 prostatic antibody; KLK 2 antibody; MGC12201antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6B7
Host
Mouse
Species Reactivity
Human
Form/Format
Purified IgG conjugated to Horseradish Peroxidase, supplied in Phosphate buffered saline (PBS) containing 0.01% Thiomersal
Purity/Purification
Protein G purified
Concentration
1mg/ml (lot specific)
Specificity
This antibody reacts with human Kallikrein 2. There is no detectable reactivity with PSA
Matching Pairs
Unconjugated Azide Free Antibody: Kallikrein 2 Clone #6B7 (MBS375062)
HRP Conjugated Antibody: Kallikrein 2 Clone #6B7 (MBS375334)
Molecular Weight
17,301 Da
OMIM
147960
3D Structure
ModBase 3D Structure for P20151
Target Antigen
Kallikrein 2
Immunogen
Line tumor cells expressing hK2
Myeloma/fusion Partners
Spleen cells from immunized BALB/c.PSA transgenic mice were fused with the P3 myeloma cell line
Research Areas
Extracellular matrix; Cytoskeleton
Applications Tested/Suitable for anti-KLK2 antibody
ELISA (EIA), Immunocytochemistry (ICC) , Immunohistochemistry (IHC) Paraffin
Application Notes for anti-KLK2 antibody
Optimal antibody dilution should be determined by titration.

Product References and Citations for anti-KLK2 antibody

Generation of monoclonal antibodies specific for human kallikrein 2 (hK2) using hK2expressing tumors. Fisher TL (Prostate,May 2002) PUBMED

Other Notes

Small volumes of anti-KLK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for KLK2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
kallikrein-2 isoform 1 preproprotein
NCBI Official Synonym Full Names
kallikrein-related peptidase 2
NCBI Official Symbol
KLK2
NCBI Official Synonym Symbols
hK2; hGK-1; KLK2A2
UniProt Protein Name
Kallikrein-2
UniProt Synonym Protein Names
Glandular kallikrein-1; hGK-1; Tissue kallikrein-2
Protein Family
UniProt Gene Name
KLK2
UniProt Synonym Gene Names
hGK-1
UniProt Entry Name
KLK2_HUMAN
NCBI Protein Information
kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; kallikrein 2, prostatic; tissue kallikrein-2

NCBI Summary for KLK2

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
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UniProt Comments for KLK2

KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.35; Protease

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KLK2 antibody

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