Poly(adp-Ribose) Polymer Antibody – Chicken Polyclonal

Background: Poly(ADP-ribose) or "pADPr" is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerase (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer pADPr, with chain lengths ranging from 2 to 300 residues, containing approximately 2% branching in the chain. pADPr becomes attached to nuclear proteins, and to PARP itself (automodification). Under normal conditions, cells display low basal level of pADPr polymer, which can dramatically increase in cells exposed to DNA damaging agents (irradiation, alkylation, etc.). This increase of polymer synthesis is usually transient and is followed by a rapid degradation phase with a short half-life which can be less than 1 min. The low endogenous level of polymer in unstimulated cells and its rapid catabolism during DNA damage has been ascribed to high activity of the polymer catabolizing enzyme poly(ADP ribose) glycohydrolase (PARG).

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Small volumes of anti-Poly(ADP-Ribose) Polymer antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS376011 is an antibody targeting Poly(ADP-Ribose) Polymer. Also known as Anti-Poly(ADP-Ribose) Polymer Chicken Polyclonal Antibody. Reactive in Does not crossreact with ADP-ribose, 5'-AMP, or yeast RNA as tested by ELISA. This antibody crossreacts to bovine serum albumin due to its use as a carrier for the immunogen.. Host: Chicken.