PLK2 Antibody – Rabbit

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

PLK2: a kinase of the PLK family. Participates in a mitotic checkpoint in which p53-dependent activation Plk2 prevents mitotic catastrophe following spindle damage. Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. Apparently plays a role for Plk2 in the cell cycle.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Tumor suppressor; EC 2.7.11.21; Protein kinase, Other; Other group; PLK family

Chromosomal Location of Human Ortholog: 5q12.1-q13.2

Cellular Component: centriole; centrosome; dendrite; intracellular

Molecular Function: protein serine/threonine kinase activity; protein binding; signal transducer activity; protein complex binding; ATP binding

Biological Process: regulation of centriole replication; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein binding; mitotic cell cycle checkpoint; regulation of synaptic plasticity; protein amino acid phosphorylation; memory; mitotic spindle organization and biogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; Ras protein signal transduction; Rap protein signal transduction; G1/S transition of mitotic cell cycle; negative regulation of apoptosis