COVID 19 Spike Protein (S1 + S2 Extracellular Domain) Coronavirus (COVID-19) Antibody – Chicken Polyclonal

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus, originated from the Wuhan region of Hubei province in China late in 2019 (1). Coronavirus invades cells through spike protein mediated binding human airway epithelial cell surface receptor Angiotensin converting enzyme 2 (ACE2). Spike protein also mediates fusion of host and viral cell membrane to begin infection (2). Spike protein is the major target for neutralizing antibodies and vaccine development (3).
The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain, which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.
Protein modeling suggests that there is a strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19 (4). A recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein (5).

1. Gorbalenya. bioRxiv: 2020.
2. Belouzard et al. Viruses. 2012;4(6):1011-33.
3. Lee et al. J Virol. 2006;80(8):4079-87.
4. Wan et al. J Virol. 2020.
5. Wrapp et al. Science. 2020.

Small volumes of anti-COVID-19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS378285 is an antibody targeting COVID-19. Also known as Chicken anti COVID19 spike protein anti-serum. Reactive in Virus. Host: Chicken.