Rabbit Anti-TBX22 Antibody – Cat# MBS003843

TBX22 Antibody – Rabbit

Name: TBX22 Antibody; Rabbit; Human-Reactive; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS003843
Price: 595 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS003843

MBS003843 is an antibody targeting TBX22. Also known as Rabbit TBX22 Antibody. Reactive in Human. Host: Rabbit. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

TBX22, Antibody

Full Product Name

Rabbit TBX22 Antibody

Product Gene Name

anti-TBX22 antibody

Host

Rabbit

Species Reactivity

Human

Form/Format

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Concentration

1 mg/ml (lot specific)

Molecular Weight

57,910 Da

Chromosome Location

Chromosome: X; NC_000023.10 (79270255..79287268). Location: Xq21.1

OMIM

300307

3D Structure

ModBase 3D Structure for Q9Y458

Applications Tested/Suitable for anti-TBX22 antibody

ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-TBX22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TBX22. It may not necessarily be applicable to this product.

NCBI GI #

158187509

NCBI GeneID

50945

NCBI Accession #

NP_001103348.1

UniProt Primary Accession #

Q9Y458

UniProt Secondary Accession #

Q5JZ06; Q96LC0; Q9HBF1

UniProt Related Accession #

Q9Y458

GenBank Nucleotide #

NM_001109878.1

NCBI Official Full Name

T-box transcription factor TBX22 isoform 1

NCBI Official Synonym Full Names

T-box 22

NCBI Official Symbol

TBX22

NCBI Official Synonym Symbols

CPX; CLPA; TBXX; ABERS; dJ795G23.1

UniProt Protein Name

T-box transcription factor TBX22

Protein Family

T-box transcription factor

UniProt Gene Name

TBX22

UniProt Synonym Gene Names

TBOX22; T-box protein 22

UniProt Entry Name

TBX22_HUMAN

NCBI Protein Information

T-box transcription factor TBX22; T-box protein 22

NCBI Summary for TBX22

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for TBX22

TBX22: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia (CPX). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent

Disease: Cleft Palate With Or Without Ankyloglossia, X-linked; Abruzzo-erickson Syndrome

Research Articles on TBX22

1. 5 putative missense mutations were identified, 3 located in T-box binding domain (R120Q, R126W, and R151L) that affects DNA binding and/or transcriptional repression. 2 novel C-terminal mutations, P389Q and S400Y, did not affect TBX22 activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-TBX22 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>24 publications with TBX22 and Congenital Abnormalities
Cleft palate X-linked Antibodies	>21 publications with TBX22 and Cleft palate X-linked
Neoplasms Antibodies	>2 publications with TBX22 and Neoplasms
Nervous System Diseases Antibodies	>1 publications with TBX22 and Nervous System Diseases
Intestinal Neoplasms Antibodies	>1 publications with TBX22 and Intestinal Neoplasms
Neurodegenerative Diseases Antibodies	>1 publications with TBX22 and Neurodegenerative Diseases
Eye Diseases Antibodies	>1 publications with TBX22 and Eye Diseases

Organs/Tissues associated with anti-TBX22 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>1 publications with TBX22 and Skin