Transforming Growth Factor Receptor (TGFR) ELISA Kit for Monkey

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; integral to plasma membrane; endoplasmic reticulum; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; heparin binding; protein binding; glycosaminoglycan binding; fibroblast growth factor binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding

Biological Process: heart morphogenesis; transforming growth factor beta receptor complex assembly; blood vessel development; blastocyst development; organ regeneration; cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of cell motility; cardiac muscle cell proliferation; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; regulation of protein binding; response to hypoxia; epithelial to mesenchymal transition; ventricular cardiac muscle morphogenesis; immune response; cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation