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CDK11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3900925

CDK11 is a member of the p34Cdc2 protein kinase family and is involved in cell cycle progression, apoptosis, and tumorigenesis. Many isoforms of CDK11 have been isolated. The p58 isoform has been shown to interact with cyclin D3 and to play an important role… More details

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Product Overview

Online Datasheet in PDF
Product Name
CDK11, Polyclonal Antibody
Full Product Name
Rabbit anti-CDK11 Antibody, Affinity Purified
Product Gene Name
anti-CDK11 antibody
Product Synonym Gene Name
CDK11A
Product Synonym Names
PITSLRE protein kinase beta SV18 isoform; PITSLRE protein kinase beta SV1 isoform; PITSLRE B; PITSLRE protein kinase beta SV16 isoform; PITSLRE protein kinase beta SV17 isoform; PITSLRE serine/threonine-protein kinase CDC2L2; PITSLRE protein kinase beta SV2 isoform; CDK11-p110; PITSLRE protein kinase beta SV6 isoform; PITSLRE; PITSLRE protein kinase beta SV3 isoform; galactosyltransferase-associated protein kinase p58/GTA; cyclin-dependent kinase 11A; cell division protein kinase 11A; cell division cycle 2-like protein kinase 2; cell division cycle 2-like 2 (PITSLRE proteins); CDK11-p46; CDC2L3; CDC2L2; CDK11-p58; p58GTA; Cyclin-dependent kinase 11A; cyclin dependent kinase 11A
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
49,624 Da
OMIM
116951
3D Structure
ModBase 3D Structure for Q9UQ88
Predicted Reactivity
Mouse
Immunogen
Between 745 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-CDK11 antibody

Primary Antibodies
Applications Tested/Suitable for anti-CDK11 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-CDK11 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:1000 to 1:5000. Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-CDK11 antibody

Detection of human CDK11 by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-CDK11 (MBS3900925 lot 4) used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Rabbit Anti-CDK11 Polyclonal Antibody – Cat# MBS3900925

Immunoprecipitation (IP) of anti-CDK11 antibody

Detection of human CDK11 by western blot of immunoprecipitates. Samples: Whole cell lysate (1.0 mg per IP reaction; 10% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-CDK11 antibody (MBS3900925 lot 4) used for IP at 6 ug per reaction. CDK11 was also immunoprecipitated by a previous lot of this antibody (MBS3900925 lot 3) and a second antibody against a different epitope of CDK11 (MBS3900924). For blotting immunoprecipitated CDK11, MBS3900925 was used at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 75 seconds.
Rabbit Anti-CDK11 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3900925

Western Blot (WB) of anti-CDK11 antibody

Detection of human CDK11 by western blot. Samples: Whole cell lysate (5 ug) from HeLa, Hep-G2, SR, K-562, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-CDK11 antibody (MBS3900925 lot 4) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-CDK11 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3900925

Other Notes

Small volumes of anti-CDK11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDK11 purchase

MBS3900925 is an antibody targeting CDK11. Also known as Rabbit anti-CDK11 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDK11. It may not necessarily be applicable to this product.

NCBI GI #
148763345
NCBI GeneID
728642
NCBI Accession #
NP_277071.2
UniProt Primary Accession #
Q9UQ88
UniProt Secondary Accession #
O95227; O95228; O96012; Q12821; Q12853; Q12854; Q2TAJ0; Q5QPR0; Q5QPR1; Q5QPR2; Q9UBC4
UniProt Related Accession #
Q9UQ88
GenBank Nucleotide #
NM_033529.2
NCBI Official Full Name
cyclin-dependent kinase 11A isoform 4
NCBI Official Synonym Full Names
cyclin-dependent kinase 11A
NCBI Official Symbol
CDK11A
NCBI Official Synonym Symbols
CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110
UniProt Protein Name
Cyclin-dependent kinase 11A
UniProt Synonym Protein Names
Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11A; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L2
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
CDK11A
UniProt Synonym Gene Names
CDC2L2; CDC2L3; PITSLREB
UniProt Entry Name
CD11A_HUMAN
NCBI Protein Information
cyclin-dependent kinase 11A; PITSLRE B; PITSLRE protein kinase beta; cell division protein kinase 11A; cell division cycle 2-like protein kinase 2; PITSLRE serine/threonine-protein kinase CDC2L2; cell division cycle 2-like 2 (PITSLRE proteins); galactosyl

UniProt Comments for CDK11

CDK11A: Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. The cleaved p110 isoform, p110C, binds to the serine/threonine kinase PAK1. The p58 isoform but not the p110 isoform or p110C interacts with CCND3. The p110 isoforms are found in large molecular weight complexes containing CCNL1 and SFRS7. The p58 isoform is specifically induced in G2/M phase of the cell cycle. Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. Phosphorylation at Thr-436 or Tyr-437 inactivates the enzyme, while phosphorylation at Thr-583 activates it. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.22; Protein kinase, CMGC; Motility/polarity/chemotaxis; Cell cycle regulation; RNA processing; CMGC group; CDK family; PITSLRE subfamily

Chromosomal Location of Human Ortholog: 1p36.33

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; cyclin-dependent protein kinase activity; ATP binding; protein kinase activity

Biological Process: mitosis; regulation of transcription, DNA-dependent; regulation of cell cycle; apoptosis; regulation of cell growth; protein amino acid phosphorylation; regulation of mRNA processing
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CDK11 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway antibodies  Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway Diagram

Diseases associated with anti-CDK11 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >5 publications with CDK11 and Necrosis
 Inflammation Antibodies  >2 publications with CDK11 and Inflammation
 Hematologic Diseases Antibodies  >1 publications with CDK11 and Hematologic Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with CDK11 and Carcinoma, Hepatocellular
 Brain Diseases Antibodies  >1 publications with CDK11 and Brain Diseases

Organs/Tissues associated with anti-CDK11 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with CDK11 and Blood
 Liver Antibodies  >5 publications with CDK11 and Liver
 Ovary Antibodies  >4 publications with CDK11 and Ovary
 Connective Tissue Antibodies  >3 publications with CDK11 and Connective Tissue
 Brain Antibodies  >3 publications with CDK11 and Brain
 Skin Antibodies  >2 publications with CDK11 and Skin
 Testis Antibodies  >2 publications with CDK11 and Testis
 Eye Antibodies  >1 publications with CDK11 and Eye
 Kidney Antibodies  >1 publications with CDK11 and Kidney
 Embryonic Tissue Antibodies  >1 publications with CDK11 and Embryonic Tissue
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