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Apolipoprotein CII (Apo CII) (APO CII) Human Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS390115

MBS390115 is a protein targeting Apo CII. Also known as Human Apolipoprotein CII (Apo CII). More details

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Product Overview

Online Datasheet in PDF
Product Name
Apolipoprotein CII (Apo CII), Protein
Full Product Name
Human Apolipoprotein CII (Apo CII)
Product Gene Name
Product Synonym Names
Human Apolipoprotein CII (Apo CII)
Purity/Purification
After series ultracentrifugations, Very Low Density Lipoprotein (VLDL) is isolated from human plasma. Apo CII is purified from delipidated VLDL, followed by gel-filtration and DEAE-Sepharcyl chromatography.
Purity: 98 % by SDS-PAGE
Concentration
0.7 mg / ml, determined by the Lowry method (lot specific)
Preparation and Storage
-20 degree C for long-term storage, 2-8 degree C for short-term storage. Aliquot to avoid repeated freezing and thawing.
Molecular Weight
11,284 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (45449239..45452822). Location: 19q13.2
OMIM
207750
3D Structure
ModBase 3D Structure for P02655
Source Note
From fresh human plasma that has tested negative for Hepatitis C, HIV-I and HIV-II antibodies as well as Hepatitis surface antigens.
Preservative
10 mM PBS, 0.15 M NaCl, 0.02 % NaN3, 0.5 mM EDTA, pH 7.2.

Product Categories/Family for Apo CII protein

Applications Tested/Suitable for Apo CII protein
SDS-PAGE
Application Notes for Apo CII protein
Purity > 98% by SDS-PAGE.

Testing Data) of Apo CII protein

Human APO CII Protein – Cat# MBS390115

Other Notes

Small volumes of Apo CII protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Apo CII. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
apolipoprotein CII
NCBI Official Synonym Full Names
apolipoprotein C-II
NCBI Official Symbol
APOC2
NCBI Official Synonym Symbols
APO-CII; APOC-II
UniProt Protein Name
Apolipoprotein C-II
UniProt Synonym Protein Names
Apolipoprotein C2
UniProt Gene Name
APOC2
UniProt Synonym Gene Names
APC2; Apo-CII; ApoC-II
UniProt Entry Name
APOC2_HUMAN
NCBI Protein Information
apolipoprotein C-II; apolipoprotein C2

NCBI Summary for Apo CII

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
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UniProt Comments for Apo CII

Function: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

Subcellular location: Secreted.

Tissue specificity: Secreted in plasma.

Involvement in disease: Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23

Sequence similarities: Belongs to the apolipoprotein C2 family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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