Pescadillo (PES1) Antibody – Rabbit Polyclonal

This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011]

PES1: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Translation; Nucleolus

Chromosomal Location of Human Ortholog: 22q12.1

Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; condensed chromosome; nucleus

Molecular Function: ribonucleoprotein binding; protein binding

Biological Process: cell proliferation; regulation of cell cycle; protein localization in organelle; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis and assembly; nucleolus organization and biogenesis; rRNA processing