KIF14 Antibody – Rabbit Polyclonal

This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

KIF14: Plays an essential role in cytokinesis. Belongs to the kinesin-like protein family.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: microtubule; kinesin complex; membrane; cytoplasm; plasma membrane; spindle midzone; midbody; nucleus

Molecular Function: tubulin binding; protein binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; microtubule motor activity; protein kinase binding; ATP binding; PDZ domain binding

Biological Process: positive regulation of cytokinesis; regulation of Rap protein signal transduction; regulation of cell adhesion; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; cerebellar granular layer structural organization; regulation of myelination; cell proliferation in forebrain; olfactory bulb development; hippocampus development; cytoskeleton-dependent intracellular transport; negative regulation of integrin activation; regulation of cell migration; mitotic metaphase plate congression; microtubule-based movement; cerebellar cortex development; establishment of protein localization; regulation of G2/M transition of mitotic cell cycle; regulation of neuron apoptosis; positive regulation of cell proliferation; activation of protein kinase activity; microtubule depolymerization; negative regulation of neuron apoptosis; cerebral cortex development; regulation of cell growth; cerebellar Purkinje cell layer structural organization; negative regulation of apoptosis

Disease: Meckel Syndrome 12