XRN2 Antibody – Rabbit Polyclonal

This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]

XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.13.-; Ribonuclease; RNA processing; RNA-binding; Cell development/differentiation; Nucleolus

Chromosomal Location of Human Ortholog: 20p11.2-p11.1

Cellular Component: membrane; nucleolus; nucleus

Molecular Function: 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; zinc ion binding

Biological Process: RNA processing; regulation of transcription, DNA-dependent; RNA metabolic process; RNA catabolic process; spermatogenesis; cell growth; mRNA processing; DNA catabolic process, exonucleolytic; transcription termination