• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

TLK2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3901762

Tousled-like kinase 2 (TLK2) is a serine/threonine kinase involved in chromatin assembly and the DNA damage response. The tousled (Tsl) kinase was first identified in Arabidopsis thaliana and speculated to be involved in cell division during patterning of… More details

$250 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TLK2, Polyclonal Antibody
Full Product Name
Rabbit anti-TLK2 Antibody, Affinity Purified
Product Gene Name
anti-TLK2 antibody
Product Synonym Names
PKU-ALPHA; serine/threonine-protein kinase tousled-like 2; MRD57; HsHPK; Tousled-like kinase 2; Serine/threonine-protein kinase tousled-like 2; tousled like kinase 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
OMIM
608439
3D Structure
ModBase 3D Structure for Q86UE8
Predicted Reactivity
Mouse
Immunogen
Between 722 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-TLK2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-TLK2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-TLK2 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-TLK2 antibody

Detection of human TLK2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) from HEK293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-TLK2 antibody (MBS3901762 lot 1) used for IP at 6 ug per reaction. TLK2 was also immunoprecipitated by a second antibody against a different epitope of TLK2 (BL2513). For blotting immunoprecipitated TLK2, MBS3901762 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-TLK2 Polyclonal Antibody – Cat# MBS3901762

Western Blot (WB) of anti-TLK2 antibody

Detection of human TLK2 by western blot. Samples: Whole cell lysate from HEK293T (50, 15 and 5 ug) and HeLa (50 ug) cells. Antibody: Affinity purified rabbit anti-TLK2 antibody (MBS3901762 lot 1) used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-TLK2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3901762

Other Notes

Small volumes of anti-TLK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TLK2 purchase

MBS3901762 is an antibody targeting TLK2. Also known as Rabbit anti-TLK2 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TLK2. It may not necessarily be applicable to this product.

NCBI GeneID
11011
NCBI Accession #
EAW94344.1
UniProt Primary Accession #
Q86UE8
UniProt Protein Name
Serine/threonine-protein kinase tousled-like 2
UniProt Synonym Protein Names
HsHPK; PKU-alpha; Tousled-like kinase 2
Protein Family
Serine/threonine-protein kinase tousled
UniProt Gene Name
TLK2
UniProt Entry Name
TLK2_HUMAN

UniProt Comments for TLK2

TLK2: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; TLK family

Chromosomal Location of Human Ortholog: 17q23

Cellular Component: perinuclear region of cytoplasm; intermediate filament; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: negative regulation of autophagy; peptidyl-serine phosphorylation; regulation of chromatin assembly or disassembly; chromatin modification; cell cycle; protein amino acid phosphorylation; response to DNA damage stimulus; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; chromosome segregation
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000