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ZHX3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3901906

ZHX3 (zinc-fingers and homeoboxes 3) was identified as a factor that heterodimerizes with the transcriptional repressor, ZHX1. ZHX3 has also been found to partner with ZHX2 and itself, as a dimer, to play a role in transcriptional repression. Recently,… More details

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Product Overview

Online Datasheet in PDF
Product Name
ZHX3, Polyclonal Antibody
Full Product Name
Rabbit anti-ZHX3 Antibody, Affinity Purified
Product Gene Name
anti-ZHX3 antibody
Product Synonym Names
TIX1; triple homeobox 1; triple homeobox protein 1; zinc finger and homeodomain protein 3; zinc fingers and homeoboxes protein 3; Zinc fingers and homeoboxes protein 3; zinc fingers and homeoboxes 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
200ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
104,658 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (39807089..39928766, complement). Location: 20q12
OMIM
609598
3D Structure
ModBase 3D Structure for Q9H4I2
Immunogen
Between 906 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-ZHX3 antibody

Primary Antibodies
Applications Tested/Suitable for anti-ZHX3 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-ZHX3 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:100-1:1000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-ZHX3 antibody

Detection of human ZHX3 by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-ZHX3 (Cat. No. MBS3901906 Lot1) used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB
Rabbit Anti-ZHX3 Polyclonal Antibody – Cat# MBS3901906

Western Blot (WB) of anti-ZHX3 antibody

Detection of human ZHX3 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-ZHX3 antibody MBS3901906 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. ZHX3 was also immunoprecipitated by rabbit anti-ZHX3 antibody MBS3901905, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 seconds (B).
Rabbit Anti-ZHX3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3901906

Other Notes

Small volumes of anti-ZHX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ZHX3 purchase

MBS3901906 is an antibody targeting ZHX3. Also known as Rabbit anti-ZHX3 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ZHX3. It may not necessarily be applicable to this product.

NCBI GI #
28827782
NCBI GeneID
23051
NCBI Accession #
NP_055850.1
UniProt Primary Accession #
Q9H4I2
UniProt Secondary Accession #
O43145; E1P5W5
UniProt Related Accession #
Q9H4I2
GenBank Nucleotide #
NM_015035.3
NCBI Official Full Name
zinc fingers and homeoboxes protein 3
NCBI Official Synonym Full Names
zinc fingers and homeoboxes 3
NCBI Official Symbol
ZHX3
NCBI Official Synonym Symbols
TIX1
UniProt Protein Name
Zinc fingers and homeoboxes protein 3
UniProt Synonym Protein Names
Triple homeobox protein 1; Zinc finger and homeodomain protein 3
Protein Family
Zinc fingers and homeoboxes protein
UniProt Gene Name
ZHX3
UniProt Synonym Gene Names
KIAA0395; TIX1
UniProt Entry Name
ZHX3_HUMAN
NCBI Protein Information
zinc fingers and homeoboxes protein 3; triple homeobox 1; triple homeobox protein 1; zinc finger and homeodomain protein 3

NCBI Summary for ZHX3

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]
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UniProt Comments for ZHX3

ZHX3: Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. Belongs to the ZHX family.

Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; metal ion binding; transcription factor activity; transcription corepressor activity

Biological Process: positive regulation of osteoblast differentiation; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cell differentiation
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Research Articles on ZHX3

1. ZHX3 is involved in the switch from the undifferentiated state of mesenchymal stem cells to an osteogenic program

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ZHX3 antibody

 Reference Product  PubMed Publications
 ZHX2 antibody  >4 publications with ZHX3 and ZHX2
 ZHX1 antibody  >4 publications with ZHX3 and ZHX1
 NFYA antibody  >1 publications with ZHX3 and NFYA

Diseases associated with anti-ZHX3 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with ZHX3 and Kidney Diseases

Organs/Tissues associated with anti-ZHX3 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Marrow Antibodies  >1 publications with ZHX3 and Bone Marrow
 Bone Antibodies  >1 publications with ZHX3 and Bone
 Kidney Antibodies  >1 publications with ZHX3 and Kidney
 Testis Antibodies  >1 publications with ZHX3 and Testis
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