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EPS15L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3902184

EPS15L1 (epidermal growth factor receptor substrate 15-like 1), also known as EPS15R (EPS15-related), is structurally related to the EPS15 protein, a protein involved in the receptor-mediated endocytosis of the EGF receptor. EPS15L1 and EPS15 both contain an… More details

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Product Overview

Online Datasheet in PDF
Product Name
EPS15L, Polyclonal Antibody
Full Product Name
Rabbit anti-EPS15L Antibody, Affinity Purified
Product Gene Name
anti-EPS15L antibody
Product Synonym Gene Name
EPS15L1
Product Synonym Names
epidermal growth factor receptor substrate EPS15R; EPS15R; epidermal growth factor receptor substrate 15-like 1; eps15-related protein; Epidermal growth factor receptor substrate 15-like 1; epidermal growth factor receptor pathway substrate 15 like 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
200ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
94,255 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (16472408..16582762, complement). Location: 19p13.11
3D Structure
ModBase 3D Structure for Q9UBC2
Immunogen
Between 814 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-EPS15L antibody

Primary Antibodies
Applications Tested/Suitable for anti-EPS15L antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-EPS15L antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Western Blot (WB) of anti-EPS15L antibody

Detection of human EPS15L1 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-EPS15L1 antibody MBS3902184 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. EPS15L1 was also immunoprecipitated by rabbit anti-EPS15L1 antibody BL6643, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).
Rabbit Anti-EPS15L Polyclonal Antibody – Cat# MBS3902184

Other Notes

Small volumes of anti-EPS15L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EPS15L purchase

MBS3902184 is an antibody targeting EPS15L. Also known as Rabbit anti-EPS15L Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EPS15L. It may not necessarily be applicable to this product.

NCBI GI #
10864047
NCBI GeneID
58513
NCBI Accession #
NP_067058.1
UniProt Primary Accession #
Q9UBC2
UniProt Related Accession #
Q69YZ4; Q9UBC2
GenBank Nucleotide #
NM_021235.1
NCBI Official Full Name
epidermal growth factor receptor substrate 15-like 1
NCBI Official Synonym Full Names
epidermal growth factor receptor pathway substrate 15-like 1
NCBI Official Symbol
EPS15L1
NCBI Official Synonym Symbols
EPS15R
UniProt Protein Name
Epidermal growth factor receptor substrate 15-like 1
UniProt Synonym Protein Names
Eps15-related protein
UniProt Gene Name
EPS15L1
UniProt Synonym Gene Names
EPS15R; Eps15R
UniProt Entry Name
EP15R_HUMAN
NCBI Protein Information
epidermal growth factor receptor substrate 15-like 1; eps15-related protein; epidermal growth factor receptor substrate EPS15R

UniProt Comments for EPS15L

EPS15R: epidermal growth factor receptor substrate protein 15R. Contains three EH domains which are implicated in endocytosis, vesicle transport and signal transduction. All three EH domains contain calcium-binding domains ofthe EF-hand type. Contains 2 UIM motifs, which are is responsible for ubiquitin recognition and monoubiquitination. May function as an adaptor between ubiquitinated proteins and the clathrin coat or other endocytic scaffolds.

Protein type: Adaptor/scaffold; Vesicle

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: membrane; plasma membrane; coated pit; nucleus

Molecular Function: protein binding; calcium ion binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; epidermal growth factor receptor signaling pathway; endocytosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EPS15L antibody

 Products by Pathway  Pathway Diagram
 EGFR Downregulation Pathway antibodies  EGFR Downregulation Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 Signaling By EGFR Pathway antibodies  Signaling By EGFR Pathway Diagram

Diseases associated with anti-EPS15L antibody

 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >1 publications with EPS15L and Mental Disorders
 Neurobehavioral Manifestations Antibodies  >1 publications with EPS15L and Neurobehavioral Manifestations

Organs/Tissues associated with anti-EPS15L antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with EPS15L and Blood
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