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YTHDC2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3903336

MBS3903336 is an antibody targeting YTHDC2. Also known as Rabbit anti-YTHDC2 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit. YTHDC2 (YTH domain containing 2) is a probable ATP-dependent RNA helicase. More details

$250 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
YTHDC2, Polyclonal Antibody
Full Product Name
Rabbit anti-YTHDC2 Antibody, Affinity Purified
Product Gene Name
Product Synonym Names
3'-5' RNA helicase YTHDC2; CAHL; CsA-associated helicase-like protein; hYTHDC2; probable ATP-dependent RNA helicase YTHDC2; YTH domain-containing protein 2; Probable ATP-dependent RNA helicase YTHDC2; YTH domain containing 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
200ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
160,248 Da
OMIM
AC093208 Genomic DNA
3D Structure
ModBase 3D Structure for Q9H6S0
Predicted Reactivity
Orangutan
Immunogen
Between 1380 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-YTHDC2 antibody

Applications Tested/Suitable for anti-YTHDC2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-YTHDC2 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Western Blot (WB) of anti-YTHDC2 antibody

Detection of human YTHDC2 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-YTHDC2 antibody MBS3903336 used for WB at 0.04 ug/ml (A) and 0.4 ug/ml (B) and used for IP at 6 ug/mg lysate. YTHDC2 was also immunoprecipitated by rabbit anti-YTHDC2 antibody MBS3903335, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 10 seconds (A) and 3 seconds (B).
Rabbit Anti-YTHDC2 Polyclonal Antibody – Cat# MBS3903336

Other Notes

Small volumes of anti-YTHDC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for YTHDC2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
probable ATP-dependent RNA helicase YTHDC2 isoform 1
NCBI Official Synonym Full Names
YTH domain containing 2
NCBI Official Symbol
YTHDC2
NCBI Official Synonym Symbols
CAHL
UniProt Protein Name
Probable ATP-dependent RNA helicase YTHDC2
UniProt Synonym Protein Names
YTH domain-containing protein 2
UniProt Gene Name
YTHDC2
NCBI Protein Information
probable ATP-dependent RNA helicase YTHDC2

NCBI Summary for YTHDC2

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]
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UniProt Comments for YTHDC2

YTHDC2: Belongs to the DEAD box helicase family. DEAH subfamily.

Protein type: EC 3.6.4.13; RNA-binding

Chromosomal Location of Human Ortholog: 5q22.2

Cellular Component: endoplasmic reticulum

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; N6-methyladenosine-containing RNA binding; protein binding; RNA binding; RNA polymerase binding; RNA-dependent ATPase activity

Biological Process: response to tumor necrosis factor; RNA processing
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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