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SLM-2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3903485

Sam68-like mammalian protein 2 (SLM-2) is an RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. SLM-2 may play a role as a negative regulator of cell growth [taken from… More details

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Product Overview

Online Datasheet in PDF
Product Name
SLM-2, Polyclonal Antibody
Full Product Name
Rabbit anti-SLM-2 Antibody, Affinity Purified
Product Gene Name
anti-SLM-2 antibody
Product Synonym Gene Name
KHDRBS3
Product Synonym Names
Sam68-like phosphotyrosine protein; TSTAR; T-STAR; SLM-2; SLM2; Sam68-like phosphotyrosine protein, T-STAR; sam68-like mammalian protein 2; SALP; RNA-binding protein T-Star; KH domain-containing, RNA-binding, signal transduction-associated protein 3; KH domain containing, RNA binding, signal transduction associated 3; Etle; etoile; KH domain-containing, RNA-binding, signal transduction-associated protein 3; KH RNA binding domain containing, signal transduction associated 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
38,800 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (136469702..136669068). Location: 8q24.2
OMIM
610421
3D Structure
ModBase 3D Structure for O75525
Immunogen
Between 175 and 225
Conjugation
Unconjugated

Product Categories/Family for anti-SLM-2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-SLM-2 antibody
Immunoprecipitation (IP)
Application Notes for anti-SLM-2 antibody
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-SLM-2 antibody

Detection of human SLM-2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-SLM-2 antibody MBS3903485 used for IP at 6 ug/mg lysate. SLM-2 was also immunoprecipitated by rabbit anti-SLM-2 antibody MBS3903484, which recognizes an upstream epitope. For blotting immunoprecipitated SLM-2, MBS3903484 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-SLM-2 Polyclonal Antibody – Cat# MBS3903485

Other Notes

Small volumes of anti-SLM-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SLM-2 purchase

MBS3903485 is an antibody targeting SLM-2. Also known as Rabbit anti-SLM-2 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SLM-2. It may not necessarily be applicable to this product.

NCBI GI #
5730073
NCBI GeneID
10656
NCBI Accession #
NP_006549.1
UniProt Primary Accession #
O75525
UniProt Secondary Accession #
Q6NUL8; Q9UPA8
UniProt Related Accession #
O75525
GenBank Nucleotide #
NM_006558.1
NCBI Official Full Name
KH domain-containing, RNA-binding, signal transduction-associated protein 3
NCBI Official Synonym Full Names
KH domain containing, RNA binding, signal transduction associated 3
NCBI Official Symbol
KHDRBS3
NCBI Official Synonym Symbols
Etle; SALP; SLM2; SLM-2; TSTAR; T-STAR; etoile
UniProt Protein Name
KH domain-containing, RNA-binding, signal transduction-associated protein 3
UniProt Synonym Protein Names
RNA-binding protein T-Star; Sam68-like mammalian protein 2; SLM-2; Sam68-like phosphotyrosine protein
Protein Family
KH domain-containing, RNA-binding, signal transduction-associated protein
UniProt Gene Name
KHDRBS3
UniProt Synonym Gene Names
SALP; SLM2; SLM-2
UniProt Entry Name
KHDR3_HUMAN
NCBI Protein Information
KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein T-Star; sam68-like mammalian protein 2; Sam68-like phosphotyrosine protein, T-STAR

UniProt Comments for SLM-2

KHDRBS3: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA- binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Belongs to the KHDRBS family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 8q24.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; RNA binding; SH3 domain binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; spermatogenesis
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Research Articles on SLM-2

1. SerpinB5 interacts with KHDRBS3 and FBXO32, and KHDRBS3 can interact with FBXO32 mRNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SLM-2 antibody

 Reference Product  PubMed Publications
 KHDRBS1 antibody  >11 publications with SLM-2 and KHDRBS1
 SIAH1 antibody  >1 publications with SLM-2 and SIAH1

Diseases associated with anti-SLM-2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with SLM-2 and Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with SLM-2 and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >1 publications with SLM-2 and Liver Diseases
 Proteinuria Antibodies  >1 publications with SLM-2 and Proteinuria
 Kidney Diseases Antibodies  >1 publications with SLM-2 and Kidney Diseases

Organs/Tissues associated with anti-SLM-2 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >7 publications with SLM-2 and Testis
 Brain Antibodies  >7 publications with SLM-2 and Brain
 Embryonic Tissue Antibodies  >2 publications with SLM-2 and Embryonic Tissue
 Muscle Antibodies  >2 publications with SLM-2 and Muscle
 Ovary Antibodies  >1 publications with SLM-2 and Ovary
 Eye Antibodies  >1 publications with SLM-2 and Eye
 Kidney Antibodies  >1 publications with SLM-2 and Kidney
 Prostate Antibodies  >1 publications with SLM-2 and Prostate
 Skin Antibodies  >1 publications with SLM-2 and Skin
 Mammary Gland Antibodies  >1 publications with SLM-2 and Mammary Gland
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