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HIP55 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3903633

HIP55 (HPK1-interacting protein of 55 kDa) is an actin-binding adapter protein that may act as a common effector of antigen receptor-signaling pathways in leukocytes. The association of HIP55 with dynamin suggests that it may also connect the actin… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
HIP55, Polyclonal Antibody
Full Product Name
Rabbit anti-HIP55 Antibody, Affinity Purified
Product Gene Name
anti-HIP55 antibody
Product Synonym Gene Name
DBNL
Product Synonym Names
SH3P7; src homology 3 domain-containing protein HIP-55; SH3 domain-containing protein 7; HPK1-interacting protein of 55 kDa; HIP-55; HIP55; drebrin-F; cervical SH3P7; cervical mucin-associated protein; actin-binding protein 1; ABP1; drebrin-like protein; Drebrin-like protein; drebrin like
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
48,207 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (44084239..44101315). Location: 7p13
OMIM
610106
3D Structure
ModBase 3D Structure for Q9UJU6
Immunogen
Between 300 and 350
Conjugation
Unconjugated

Product Categories/Family for anti-HIP55 antibody

Primary Antibodies
Applications Tested/Suitable for anti-HIP55 antibody
Immunoprecipitation (IP)
Application Notes for anti-HIP55 antibody
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-HIP55 antibody

Detection of human HIP55 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-HIP55 antibody MBS3903633 used for IP at 6 ug/mg lysate. HIP55 was also immunoprecipitated by rabbit anti-HIP55 antibody MBS3903632, which recognizes an upstream epitope. For blotting immunoprecipitated HIP55, MBS3903632 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 1 second.
Rabbit Anti-HIP55 Polyclonal Antibody – Cat# MBS3903633

Other Notes

Small volumes of anti-HIP55 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HIP55 purchase

MBS3903633 is an antibody targeting HIP55. Also known as Rabbit anti-HIP55 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HIP55. It may not necessarily be applicable to this product.

NCBI GI #
62198235
NCBI GeneID
28988
NCBI Accession #
NP_001014436.1
UniProt Primary Accession #
Q9UJU6
UniProt Secondary Accession #
P84070; Q6IAI8; Q96F30; Q96K74; Q9HBN8; Q9NR72; A4D2I9
UniProt Related Accession #
Q9UJU6
GenBank Nucleotide #
NM_001014436.2
NCBI Official Full Name
drebrin-like protein isoform b
NCBI Official Synonym Full Names
drebrin-like
NCBI Official Symbol
DBNL
NCBI Official Synonym Symbols
ABP1; SH3P7; HIP-55
UniProt Protein Name
Drebrin-like protein
UniProt Synonym Protein Names
Cervical SH3P7; Cervical mucin-associated protein; Drebrin-F; HPK1-interacting protein of 55 kDa; HIP-55; SH3 domain-containing protein 7
UniProt Gene Name
DBNL
UniProt Synonym Gene Names
CMAP; SH3P7; HIP-55
UniProt Entry Name
DBNL_HUMAN
NCBI Protein Information
drebrin-like protein; drebrin-F; cervical SH3P7; SH3 domain-containing protein 7; cervical mucin-associated protein; HPK1-interacting protein of 55 kDa; src homology 3 domain-containing protein HIP-55

UniProt Comments for HIP55

DBNL: an SH3-containing adaptor protein. Interacts with hematopoietic progenitor kinase 1a (HIPK1). It is recruited to glycolipid-enriched microdomains following T cell receptor (TCR) stimulation. Interacts with and is phosphorylated by ZAP-70 after TCR signaling. May regulate JNK activation following TCR signaling, presumably via its interaction with HIPKIt is a member of the drebrin family of proteins that are developmentally regulated in the brain.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 7p13

Cellular Component: Golgi membrane; ruffle; lamellipodium; dendrite; postsynaptic density; cytoplasm; plasma membrane; clathrin coated vesicle membrane; podosome; cell cortex; cytosol; cell junction

Molecular Function: actin filament binding; protein C-terminus binding; protein domain specific binding; protein binding; enzyme activator activity; actin binding

Biological Process: receptor-mediated endocytosis; synaptogenesis; immune system process; apoptosis; Rac protein signal transduction; neurite morphogenesis; activation of JNK activity; cell structure disassembly during apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HIP55 antibody

 Reference Product  PubMed Publications
 SYK antibody  >3 publications with HIP55 and SYK

Pathways associated with anti-HIP55 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 JNK Signaling In The CD4+ TCR Pathway antibodies  JNK Signaling In The CD4+ TCR Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 TCR Signaling In Naive CD4+ T Cells Pathway antibodies  TCR Signaling In Naive CD4+ T Cells Pathway Diagram

Diseases associated with anti-HIP55 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1 publications with HIP55 and Necrosis
 Status Epilepticus Antibodies  >1 publications with HIP55 and Status Epilepticus
 Cardiovascular Diseases Antibodies  >1 publications with HIP55 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with HIP55 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with HIP55 and Inflammation

Organs/Tissues associated with anti-HIP55 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with HIP55 and Brain
 Muscle Antibodies  >3 publications with HIP55 and Muscle
 Blood Antibodies  >3 publications with HIP55 and Blood
 Spleen Antibodies  >2 publications with HIP55 and Spleen
 Heart Antibodies  >1 publications with HIP55 and Heart
 Embryonic Tissue Antibodies  >1 publications with HIP55 and Embryonic Tissue
 Thymus Antibodies  >1 publications with HIP55 and Thymus
 Lung Antibodies  >1 publications with HIP55 and Lung
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