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MetAP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3903690

Methionine aminopeptidase 2 (MetAP) removes the amino-terminal methionine from nascent proteins. The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is… More details

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Product Overview

Online Datasheet in PDF
Product Name
MetAP2, Polyclonal Antibody
Full Product Name
Rabbit anti-MetAP2 Antibody, Affinity Purified
Product Gene Name
anti-MetAP2 antibody
Product Synonym Gene Name
METAP2
Product Synonym Names
MAP 2; testicular tissue protein Li 17; peptidase M 2; Peptidase M; p67eIF2; p67; MNPEP; methionine aminopeptidase 2; MAP2; initiation factor 2-associated 67 kDa glycoprotein; eIF-2-associated p67 homolog; MetAP 2; Methionine aminopeptidase 2; methionyl aminopeptidase 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
50,510 Da
3D Structure
ModBase 3D Structure for P50579
Predicted Reactivity
Bovine
Immunogen
Between 100 and 150
Conjugation
Unconjugated

Product Categories/Family for anti-MetAP2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-MetAP2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-MetAP2 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Western Blot (WB) of anti-MetAP2 antibody

Detection of human and mouse MetAP2 by western blot (h and m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 ug), Jurkat (J; 50 ug) and mouse NIH 3T3 (M; 50 ug) cells. Antibodies: Affinity purified rabbit anti-MetAP2 antibody MBS3903690 used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. MetAP2 was also immunoprecipitated by rabbit anti-MetAP2 antibody BL12275, which recognizes a downstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).
Rabbit Anti-MetAP2 Polyclonal Antibody – Cat# MBS3903690

Other Notes

Small volumes of anti-MetAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MetAP2 purchase

MBS3903690 is an antibody targeting MetAP2. Also known as Rabbit anti-MetAP2 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MetAP2. It may not necessarily be applicable to this product.

NCBI GI #
5803092
NCBI GeneID
10988
NCBI Accession #
NP_006829.1
UniProt Primary Accession #
P50579
UniProt Secondary Accession #
Q8NB11; B2RDI8; B4DUX5; G3XA91
UniProt Related Accession #
P50579
GenBank Nucleotide #
NM_006838.3
NCBI Official Full Name
methionine aminopeptidase 2 isoform 1
NCBI Official Synonym Full Names
methionyl aminopeptidase 2
NCBI Official Symbol
METAP2
NCBI Official Synonym Symbols
MAP2; MNPEP; p67eIF2
UniProt Protein Name
Methionine aminopeptidase 2
UniProt Synonym Protein Names
Initiation factor 2-associated 67 kDa glycoproteinUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; p67UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; p67eIF2UniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175; Peptidase MUniRule annotationManual assertion according to rulesiHAMAP-Rule:MF_03175
UniProt Gene Name
METAP2
UniProt Synonym Gene Names
MNPEP; P67EIF2; MAP 2
NCBI Protein Information
methionine aminopeptidase 2

NCBI Summary for MetAP2

The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
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UniProt Comments for MetAP2

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
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Research Articles on MetAP2

1. MetAP1 and MetAP2 have roles in driving cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MetAP2 antibody

 Reference Product  PubMed Publications
 METAP1 antibody  >20 publications with MetAP2 and METAP1
 S100A4 antibody  >2 publications with MetAP2 and S100A4

Pathways associated with anti-MetAP2 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With Visual Transduction Pathway antibodies  Diseases Associated With Visual Transduction Pathway Diagram
 Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway antibodies  Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 The Phototransduction Cascade Pathway antibodies  The Phototransduction Cascade Pathway Diagram
 Visual Phototransduction Pathway antibodies  Visual Phototransduction Pathway Diagram

Diseases associated with anti-MetAP2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with MetAP2 and Neoplasms
 Disease Models, Animal Antibodies  >13 publications with MetAP2 and Disease Models, Animal
 Liver Diseases Antibodies  >9 publications with MetAP2 and Liver Diseases
 Liver Neoplasms Antibodies  >8 publications with MetAP2 and Liver Neoplasms
 Adenocarcinoma Antibodies  >6 publications with MetAP2 and Adenocarcinoma
 Liver Neoplasms, Experimental Antibodies  >5 publications with MetAP2 and Liver Neoplasms, Experimental
 Inflammation Antibodies  >4 publications with MetAP2 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >3 publications with MetAP2 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >3 publications with MetAP2 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with MetAP2 and Neoplasm Metastasis

Organs/Tissues associated with anti-MetAP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >27 publications with MetAP2 and Vascular
 Blood Antibodies  >15 publications with MetAP2 and Blood
 Liver Antibodies  >11 publications with MetAP2 and Liver
 Umbilical Cord Antibodies  >6 publications with MetAP2 and Umbilical Cord
 Embryonic Tissue Antibodies  >5 publications with MetAP2 and Embryonic Tissue
 Lung Antibodies  >4 publications with MetAP2 and Lung
 Lymph Antibodies  >3 publications with MetAP2 and Lymph
 Brain Antibodies  >3 publications with MetAP2 and Brain
 Prostate Antibodies  >2 publications with MetAP2 and Prostate
 Connective Tissue Antibodies  >2 publications with MetAP2 and Connective Tissue
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