Dynamin 2 (DNM2) Antibody – Rabbit Polyclonal

DYN2: a cytoplasmic microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. May mediate the conventional clathrin-mediated uptake of surface receptors. Expressed in the postsynaptic density of neuronal cells. Two alternatively spliced isoforms have been described.

Protein type: Hydrolase; EC 3.6.5.5; Vesicle; Motility/polarity/chemotaxis; Microtubule-binding

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: Golgi membrane; Golgi apparatus; microtubule; postsynaptic membrane; focal adhesion; growth cone; cytoplasm; postsynaptic density; plasma membrane; coated pit; midbody; cytosol

Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; microtubule binding; SH3 domain binding

Biological Process: receptor-mediated endocytosis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; synaptic vesicle transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; transferrin transport; endocytosis; regulation of axon extension; signal transduction; nitric oxide metabolic process; regulation of transcription, DNA-dependent; receptor internalization; regulation of nitric-oxide synthase activity; post-Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; neurite morphogenesis

Disease: Lethal Congenital Contracture Syndrome 5; Myopathy, Centronuclear, 1; Charcot-marie-tooth Disease, Dominant Intermediate B