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PSMD2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904098

PSMD2 [proteasome (prosome, macropain) 26S subunit, non-ATPase, 2] is a subunit of the 26 S proteasome. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S… More details

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Product Overview

Online Datasheet in PDF
Product Name
PSMD2, Polyclonal Antibody
Full Product Name
Rabbit anti-PSMD2 Antibody, Affinity Purified
Product Gene Name
anti-PSMD2 antibody
Product Synonym Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; tumor necrosis factor type 1 receptor-associated protein 2; TRAP2; TNFR-associated protein 2; S2; protein 55.11; P97; 55.11 protein; 26S proteasome subunit p97; 26S proteasome regulatory subunit S2; 26S proteasome regulatory subunit RPN1; 26S proteasome non-ATPase regulatory subunit 2; RPN1; 26S proteasome non-ATPase regulatory subunit 2; proteasome 26S subunit, non-ATPase 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
100,200 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (184017022..184026840). Location: 3q27.1
OMIM
606223
3D Structure
ModBase 3D Structure for Q13200
Predicted Reactivity
Rat, Bovine, Orangutan
Immunogen
Between 50 and 100
Conjugation
Unconjugated

Product Categories/Family for anti-PSMD2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-PSMD2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-PSMD2 antibody
WB: 1:1000-1:5000
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-PSMD2 antibody

Detection of human PCMD2 by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-PSMD2 (Cat. No. MBS3904098 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-PSMD2 Polyclonal Antibody – Cat# MBS3904098

Immunohistochemistry (IHC) of anti-PSMD2 antibody

Detection of mouse PCMD2 by immunohistochemistry. Sample: FFPE section of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti-PSMD2 (Cat. No. MBS3904098 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-PSMD2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3904098

Immunoprecipitation (IP) of anti-PSMD2 antibody

Detection of human PCMD2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from HEK293T cells. Antibodies: Affinity purified rabbit anti-PSMD2 antibody MBS3904098 (lot MBS3904098-1) used for IP at 6 ug/mg lysate. PSMD2 was also immunoprecipitated by rabbit anti-PSMD2 antibody MBS3904097. For blotting immunoprecipitated PSMD2, MBS3904098 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 seconds.
Rabbit Anti-PSMD2 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904098

Western Blot (WB) of anti-PSMD2 antibody

Detection of mouse PSMD2 by western blot. Samples: Whole cell lysate (50 ug) from NIH 3T3 cells. Antibodies: Affinity purified rabbit anti-PSMD2 antibody MBS3904098 (lot MBS3904098-1) used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-PSMD2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904098

Western Blot (WB) of anti-PSMD2 antibody

Detection of human PSMD2 by western blot. Samples: Whole cell lysate from HEK293T (15 and 50 ug), HeLa (H; 50 ug) and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-PSMD2 antibody MBS3904098 (lot MBS3904098-1) used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-PSMD2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904098

Other Notes

Small volumes of anti-PSMD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSMD2 purchase

MBS3904098 is an antibody targeting PSMD2. Also known as Rabbit anti-PSMD2 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSMD2. It may not necessarily be applicable to this product.

NCBI GI #
25777602
NCBI GeneID
5708
NCBI Accession #
NP_002799.3
UniProt Primary Accession #
Q13200
UniProt Secondary Accession #
Q12932; Q15321; Q53XQ4; Q96I12
UniProt Related Accession #
Q13200
GenBank Nucleotide #
NM_002808.3
NCBI Official Full Name
26S proteasome non-ATPase regulatory subunit 2
NCBI Official Synonym Full Names
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
NCBI Official Symbol
PSMD2
NCBI Official Synonym Symbols
S2; P97; Rpn1; TRAP2
UniProt Protein Name
26S proteasome non-ATPase regulatory subunit 2
UniProt Synonym Protein Names
26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; Protein 55.11; Tumor necrosis factor type 1 receptor-associated protein 2
Protein Family
26S proteasome non-ATPase regulatory
UniProt Gene Name
PSMD2
UniProt Synonym Gene Names
TRAP2
UniProt Entry Name
PSMD2_HUMAN
NCBI Protein Information
26S proteasome non-ATPase regulatory subunit 2; 55.11 protein; protein 55.11; TNFR-associated protein 2; 26S proteasome subunit p97; 26S proteasome regulatory subunit S2; 26S proteasome regulatory subunit RPN1; tumor necrosis factor receptor-associated pr

NCBI Summary for PSMD2

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. [provided by RefSeq, Jul 2008]
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UniProt Comments for PSMD2

PSMD2: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the proteasome subunit S2 family.

Protein type: Cell cycle regulation; Proteasome complex

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: proteasome complex; nucleoplasm; membrane; proteasome regulatory particle; cytosol

Molecular Function: protein binding; enzyme regulator activity

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of apoptosis; G1/S transition of mitotic cell cycle
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Research Articles on PSMD2

1. Results suggest that PSMD2 may be a good molecular target candidate.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSMD2 antibody

 Reference Product  PubMed Publications
 PSMC2 antibody  >2 publications with PSMD2 and PSMC2
 TNFRSF1A antibody  >1 publications with PSMD2 and TNFRSF1A
 PSMD5 antibody  >1 publications with PSMD2 and PSMD5
 PSMC1 antibody  >1 publications with PSMD2 and PSMC1

Pathways associated with anti-PSMD2 antibody

 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Activation Of NF-kappaB In B Cells Pathway antibodies  Activation Of NF-kappaB In B Cells Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram

Diseases associated with anti-PSMD2 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >17 publications with PSMD2 and Necrosis
 Neoplasms Antibodies  >3 publications with PSMD2 and Neoplasms
 Death Antibodies  >3 publications with PSMD2 and Death
 Heart Diseases Antibodies  >1 publications with PSMD2 and Heart Diseases
 Drug Toxicity Antibodies  >1 publications with PSMD2 and Drug Toxicity
 Fibrosis Antibodies  >1 publications with PSMD2 and Fibrosis
 Atrophy Antibodies  >1 publications with PSMD2 and Atrophy
 Inflammation Antibodies  >1 publications with PSMD2 and Inflammation

Organs/Tissues associated with anti-PSMD2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with PSMD2 and Blood
 Muscle Antibodies  >2 publications with PSMD2 and Muscle
 Lung Antibodies  >2 publications with PSMD2 and Lung
 Nerve Antibodies  >1 publications with PSMD2 and Nerve
 Vascular Antibodies  >1 publications with PSMD2 and Vascular
 Heart Antibodies  >1 publications with PSMD2 and Heart
 Skin Antibodies  >1 publications with PSMD2 and Skin
 Brain Antibodies  >1 publications with PSMD2 and Brain
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