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Exportin-T (XPOT) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904208

Exportin T is a member of the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN [taken from NCBI Entrez Gene (Gene ID:… More details

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Product Overview

Online Datasheet in PDF
Product Name
Exportin-T (XPOT), Polyclonal Antibody
Full Product Name
Rabbit anti-Exportin-T Antibody, Affinity Purified
Product Gene Name
anti-XPOT antibody
Product Synonym Names
tRNA exportin; XPO3; exportin, tRNA (nuclear export receptor for tRNAs); exportin(tRNA); exportin-T; Exportin-T; exportin for tRNA
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
109,964 Da
OMIM
603180
3D Structure
ModBase 3D Structure for O43592
Predicted Reactivity
Orangutan
Immunogen
Between 825 and 875
Conjugation
Unconjugated

Product Categories/Family for anti-XPOT antibody

Primary Antibodies
Applications Tested/Suitable for anti-XPOT antibody
Western Blot (WB)
Application Notes for anti-XPOT antibody
WB: 1:1000-1:5000

Immunoprecipitation (IP) of anti-XPOT antibody

Detection of human Exportin-T by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from HEK293T cells. Antibodies: Affinity purified rabbit anti-Exportin-T antibody MBS3904208 (lot MBS3904208-1) used for IP at 6 ug/mg lysate. Exportin-T was also immunoprecipitated by rabbit anti-Exportin-T antibody MBS3904209. For blotting immunoprecipitated Exportin-T, MBS3904208 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-XPOT Polyclonal Antibody – Cat# MBS3904208

Western Blot (WB) of anti-XPOT antibody

Detection of human and mouse Exportin-T by western blot. Samples: Whole cell lysate (50 ug) from HEK293T, HeLa, Jurkat, and mouse TCMK-1 cells. Antibodies: Affinity purified rabbit anti-Exportin-T antibody MBS3904208 (lot MBS3904208-1) used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-XPOT Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904208

Other Notes

Small volumes of anti-XPOT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for XPOT purchase

MBS3904208 is an antibody targeting XPOT. Also known as Rabbit anti-Exportin-T Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for XPOT. It may not necessarily be applicable to this product.

NCBI GI #
317108146
NCBI GeneID
11260
NCBI Accession #
NP_009166.2
UniProt Primary Accession #
O43592
UniProt Secondary Accession #
O43784; Q8WUG2; Q9BVS7; A6NLH1
UniProt Related Accession #
O43592
GenBank Nucleotide #
NM_007235
NCBI Official Full Name
Homo sapiens exportin, tRNA (XPOT), mRNA
NCBI Official Synonym Full Names
exportin, tRNA
NCBI Official Symbol
XPOT
NCBI Official Synonym Symbols
XPO3
UniProt Protein Name
Exportin-T
UniProt Synonym Protein Names
Exportin(tRNA); tRNA exportin
Protein Family
Exportin
UniProt Gene Name
XPOT
UniProt Entry Name
XPOT_HUMAN
NCBI Protein Information
exportin-T; exportin(tRNA); exportin, tRNA (nuclear export receptor for tRNAs); tRNA exportin

NCBI Summary for XPOT

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN. [provided by RefSeq, Jul 2008]

UniProt Comments for XPOT

exportin T: Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family.

Protein type: Nuclear import; Karyopherin; Nuclear export

Chromosomal Location of Human Ortholog: 12q14.2

Cellular Component: nucleoplasm; cytoplasm; nuclear pore

Molecular Function: Ran GTPase binding; tRNA binding

Biological Process: intracellular protein transport; tRNA export from nucleus
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Research Articles on XPOT

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-XPOT antibody

 Reference Product  PubMed Publications
 RAN antibody  >10 publications with XPOT and RAN
 RANBP2 antibody  >1 publications with XPOT and RANBP2
 NUP214 antibody  >1 publications with XPOT and NUP214
 XPO7 antibody  >1 publications with XPOT and XPO7
 NUP153 antibody  >1 publications with XPOT and NUP153

Pathways associated with anti-XPOT antibody

 Products by Pathway  Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram
 RNA Transport Pathway antibodies  RNA Transport Pathway Diagram

Diseases associated with anti-XPOT antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >1 publications with XPOT and Pain
 Nerve Degeneration Antibodies  >1 publications with XPOT and Nerve Degeneration
 Inflammation Antibodies  >1 publications with XPOT and Inflammation

Organs/Tissues associated with anti-XPOT antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >2 publications with XPOT and Skin
 Bladder Antibodies  >1 publications with XPOT and Bladder
 Eye Antibodies  >1 publications with XPOT and Eye
 Liver Antibodies  >1 publications with XPOT and Liver
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