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CaMKK2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904244

Calcium/calmodulin-dependent protein kinase kinase 2 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of the CAMKK2 gene plays a role in the calcium/calmodulin-dependent… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CaMKK2, Polyclonal Antibody
Full Product Name
Rabbit anti-CaMKK2 Antibody, Affinity Purified
Product Gene Name
anti-CaMKK2 antibody
Product Synonym Names
CaMKK 2; CAMKKB; CAMKK beta protein; caM-KK beta; CaMKK beta; caM-KK 2; caM-kinase kinase beta; caM-kinase kinase 2; Calcium/calmodulin-dependent protein kinase kinase beta; calcium/calmodulin-dependent protein kinase kinase 2, beta; calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase beta; CAMKK; Calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin dependent protein kinase kinase 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
OMIM
615002
3D Structure
ModBase 3D Structure for Q96RR4
Predicted Reactivity
Rat
Immunogen
Between 538 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-CaMKK2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-CaMKK2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-CaMKK2 antibody
WB: 1:500-1:2500
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-CaMKK2 antibody

Detection of human CaMKK2 by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-CaMKK2 (Cat. No. MBS3904244 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-CaMKK2 Polyclonal Antibody – Cat# MBS3904244

Immunoprecipitation (IP) of anti-CaMKK2 antibody

Detection of human CaMKK2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from HEK293T cells. Antibodies: Affinity purified rabbit anti-CaMKK2 antibody MBS3904244 (lot MBS3904244-1) used for IP at 6 ug/mg lysate. For blotting immunoprecipitated CaMKK2, MBS3904244 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-CaMKK2 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904244

Western Blot (WB) of anti-CaMKK2 antibody

Detection of human CaMKK2 by western blot. Samples: Whole cell lysate (50 ug) from HEK293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-CaMKK2 antibody MBS3904244 (lot MBS3904244-1) used for WB at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-CaMKK2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904244

Other Notes

Small volumes of anti-CaMKK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CaMKK2 purchase

MBS3904244 is an antibody targeting CaMKK2. Also known as Rabbit anti-CaMKK2 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CaMKK2. It may not necessarily be applicable to this product.

NCBI GeneID
10645
NCBI Accession #
NP_757364.1
UniProt Primary Accession #
Q96RR4
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase kinase 2
UniProt Synonym Protein Names
Calcium/calmodulin-dependent protein kinase kinase beta
Protein Family
Calcium/calmodulin-dependent protein kinase
UniProt Gene Name
CAMKK2
UniProt Synonym Gene Names
CAMKKB; KIAA0787; CaM-KK 2; CaM-kinase kinase 2; CaMKK 2; CaM-KK beta; CaM-kinase kinase beta; CaMKK beta
UniProt Entry Name
KKCC2_HUMAN

UniProt Comments for CaMKK2

CAMKK2: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Seems to be involved in hippocampal activation of CREB1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Protein kinase, Other; EC 2.7.11.17; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; CAMKK family; Meta subfamily

Chromosomal Location of Human Ortholog: 12q24.2

Cellular Component: cell projection; cytoplasm; intracellular; nucleus

Molecular Function: calmodulin binding; calmodulin-dependent protein kinase activity; protein-tyrosine kinase activity; calcium ion binding; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; protein amino acid autophosphorylation; MAPKKK cascade; calcium-mediated signaling; regulation of protein kinase activity; protein amino acid phosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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