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DENTT Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904247

Differentially-expressed nucleolar TGF-beta1 target protein (DENTT) is part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. DENTT may… More details

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Product Overview

Online Datasheet in PDF
Product Name
DENTT, Polyclonal Antibody
Full Product Name
Rabbit anti-DENTT Antibody, Affinity Purified
Product Gene Name
anti-DENTT antibody
Product Synonym Gene Name
TSPYL2
Product Synonym Names
differentially-expressed nucleolar TGF-beta1 target protein; HRIHFB2216; NP79; nuclear protein of 79 kDa; SE204; testis-specific protein Y encoded-like 2; testis-specific Y-encoded-like protein 2; TSPX; differentially expressed nucleolar TGF-beta1 target; TSPY-like protein 2; cell division autoantigen 1; CDA1; DENTT; CASK-interacting nucleosome assembly protein; CINAP; CTCL; CTCL tumor antigen se20-4; CTCL-associated antigen se20-4; cutaneous T-cell lymphoma-associated antigen se20-4; cutaneous T-cell lymphoma-associated tumor antigen se20-4; Testis-specific Y-encoded-like protein 2; TSPY like 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
79,435 Da
OMIM
300564
3D Structure
ModBase 3D Structure for Q9H2G4
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-DENTT antibody

Primary Antibodies
Applications Tested/Suitable for anti-DENTT antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-DENTT antibody
WB: 1:1000-1:5000
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-DENTT antibody

Detection of human DENTT by immunohistochemistry. Samples: FFPE serial sections of human lung cancer. Antibody: Affinity purified rabbit anti-DENTT (Cat. No. MBS3904247 Lot1, left image and Cat. No. MBS3904248 Lot1, right image) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-DENTT Polyclonal Antibody – Cat# MBS3904247

Immunohistochemistry (IHC) of anti-DENTT antibody

Detection of human DENTT by immunohistochemistry. Samples: FFPE serial sections of human testis. Antibody: Affinity purified rabbit anti-DENTT (Cat. No. MBS3904247 Lot1, left image and Cat. No. MBS3904248 Lot1, right image) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-DENTT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3904247

Immunoprecipitation (IP) of anti-DENTT antibody

Detection of human DENTT by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-DENTT antibody MBS3904247 (lot MBS3904247-1) used for IP at 6 ug/mg lysate. DENTT was inefficiently immunoprecipitated by rabbit anti-DENTT antibody MBS3904248. For blotting immunoprecipitated DENTT, MBS3904247 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-DENTT Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904247

Western Blot (WB) of anti-DENTT antibody

Detection of human DENTT by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells. Antibodies: Affinity purified rabbit anti-DENTT antibody MBS3904247 (lot MBS3904247-1) used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-DENTT Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904247

Other Notes

Small volumes of anti-DENTT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DENTT purchase

MBS3904247 is an antibody targeting DENTT. Also known as Rabbit anti-DENTT Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DENTT. It may not necessarily be applicable to this product.

NCBI GI #
11545835
NCBI GeneID
64061
NCBI Accession #
NP_071400.1
UniProt Primary Accession #
Q9H2G4
UniProt Secondary Accession #
O94799; Q96DG7; Q9BZW6
UniProt Related Accession #
Q9H2G4
GenBank Nucleotide #
NM_022117.3
NCBI Official Full Name
testis-specific Y-encoded-like protein 2
NCBI Official Synonym Full Names
TSPY-like 2
NCBI Official Symbol
TSPYL2
NCBI Official Synonym Symbols
CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
UniProt Protein Name
Testis-specific Y-encoded-like protein 2
UniProt Synonym Protein Names
Cell division autoantigen 1; Cutaneous T-cell lymphoma-associated antigen se20-4; CTCL-associated antigen se20-4; Differentially-expressed nucleolar TGF-beta1 target protein; Nuclear protein of 79 kDa; NP79
UniProt Gene Name
TSPYL2
UniProt Synonym Gene Names
CDA1; DENTT; TSPX; TSPY-like protein 2; CTCL-associated antigen se20-4; NP79
UniProt Entry Name
TSYL2_HUMAN
NCBI Protein Information
testis-specific Y-encoded-like protein 2; TSPY-like protein 2; CTCL tumor antigen se20-4; nuclear protein of 79 kDa; cell division autoantigen 1; CTCL-associated antigen se20-4; testis-specific protein Y encoded-like 2; CASK-interacting nucleosome assembl

NCBI Summary for DENTT

This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
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UniProt Comments for DENTT

TSPYL2: Part of the CASK/TRB1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. Belongs to the nucleosome assembly protein (NAP) family.

Protein type: Transcription regulation; DNA replication

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; nucleolus; nucleus

Molecular Function: rDNA binding

Biological Process: transcription, DNA-dependent; unfolded protein response; regulation of signal transduction; chromatin modification; cell cycle; negative regulation of cell cycle; nucleosome assembly; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; regulation of transcription, DNA-dependent; negative regulation of DNA replication; negative regulation of cell growth; regulation of protein kinase activity
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Research Articles on DENTT

1. The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DENTT antibody

 Reference Product  PubMed Publications
 TGFB1 antibody  >2 publications with DENTT and TGFB1

Pathways associated with anti-DENTT antibody

 Products by Pathway  Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
 XBP1(S) Activates Chaperone Genes Pathway antibodies  XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with anti-DENTT antibody

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >2 publications with DENTT and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with DENTT and Carcinoma, Hepatocellular
 Leiomyoma Antibodies  >1 publications with DENTT and Leiomyoma
 Adenocarcinoma Antibodies  >1 publications with DENTT and Adenocarcinoma
 Hypertrophy Antibodies  >1 publications with DENTT and Hypertrophy
 Cardiovascular Diseases Antibodies  >1 publications with DENTT and Cardiovascular Diseases
 Kidney Diseases Antibodies  >1 publications with DENTT and Kidney Diseases
 Endometrial Neoplasms Antibodies  >1 publications with DENTT and Endometrial Neoplasms

Organs/Tissues associated with anti-DENTT antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with DENTT and Brain
 Testis Antibodies  >2 publications with DENTT and Testis
 Kidney Antibodies  >1 publications with DENTT and Kidney
 Connective Tissue Antibodies  >1 publications with DENTT and Connective Tissue
 Uterus Antibodies  >1 publications with DENTT and Uterus
 Embryonic Tissue Antibodies  >1 publications with DENTT and Embryonic Tissue
 Placenta Antibodies  >1 publications with DENTT and Placenta
 Blood Antibodies  >1 publications with DENTT and Blood
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