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RRAGC/RagC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904254

Ras-related GTP-binding protein C (RagC) has guanine nucleotide-binding activity but weak intrinsic GTPase activity. RagC is probably required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase… More details

$250 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RRAGC/RagC, Polyclonal Antibody
Full Product Name
Rabbit anti-RRAGC/RagC Antibody, Affinity Purified
Product Gene Name
anti-RRAGC/RagC antibody
Product Synonym Gene Name
RRAGC
Product Synonym Names
GTPase-interacting protein 2; GTR2; Rag C; Rag C protein; RAGC; ras-related GTP-binding protein C; TIB929; Ras-related GTP-binding protein C; Ras related GTP binding C
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
46.7 kDa
OMIM
608267
3D Structure
ModBase 3D Structure for Q9HB90
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-RRAGC/RagC antibody

Primary Antibodies
Applications Tested/Suitable for anti-RRAGC/RagC antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-RRAGC/RagC antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-RRAGC/RagC antibody

Detection of human RRAGC/RagC by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from HEK293T cells. Antibodies: Affinity purified rabbit anti-RRAGC/RagC antibody MBS3904254 (lot MBS3904254-1) used for IP at 6 ug/mg lysate. RRAGC/RagC was also immunoprecipitated by rabbit anti-RRAGC/RagC antibody BL14630. For blotting immunoprecipitated RRAGC/RagC, MBS3904254 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-RRAGC/RagC Polyclonal Antibody – Cat# MBS3904254

Western Blot (WB) of anti-RRAGC/RagC antibody

Detection of human and mouse RRAGC/RagC by western blot. Samples: Whole cell lysate (50 ug) from HEK293T, HeLa, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells. Antibodies: Affinity purified rabbit anti-RRAGC/RagC antibody MBS3904254 (lot MBS3904254-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-RRAGC/RagC Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904254

Other Notes

Small volumes of anti-RRAGC/RagC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RRAGC/RagC purchase

MBS3904254 is an antibody targeting RRAGC/RagC. Also known as Rabbit anti-RRAGC/RagC Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RRAGC/RagC. It may not necessarily be applicable to this product.

NCBI GI #
11995472
NCBI GeneID
64121
NCBI Accession #
NP_071440.1
UniProt Primary Accession #
Q9HB90
UniProt Secondary Accession #
Q9H202; Q9H8Q8
UniProt Related Accession #
Q9HB90
GenBank Nucleotide #
NM_022157.2
NCBI Official Full Name
ras-related GTP-binding protein C isoform 1
NCBI Official Synonym Full Names
Ras-related GTP binding C
NCBI Official Symbol
RRAGC
NCBI Official Synonym Symbols
GTR2; RAGC; TIB929
UniProt Protein Name
Ras-related GTP-binding protein C
UniProt Synonym Protein Names
GTPase-interacting protein 2; TIB929
UniProt Gene Name
RRAGC
UniProt Synonym Gene Names
Rag C; RagC
UniProt Entry Name
RRAGC_HUMAN
NCBI Protein Information
ras-related GTP-binding protein C

UniProt Comments for RRAGC/RagC

RRAGC: Has guanine nucleotide-binding activity but weak intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family.

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; lysosome; cytoplasm; nucleus

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; protein heterodimerization activity; magnesium ion binding

Biological Process: transcription, DNA-dependent; apoptosis; RNA splicing; small GTPase mediated signal transduction; regulation of autophagy; cellular response to starvation; cell growth; positive regulation of TOR signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RRAGC/RagC antibody

 Reference Product  PubMed Publications
 RRAGD antibody  >6 publications with RRAGC/RagC and RRAGD
 RHEB antibody  >4 publications with RRAGC/RagC and RHEB
 MTOR antibody  >4 publications with RRAGC/RagC and MTOR
 RRAGA antibody  >4 publications with RRAGC/RagC and RRAGA
 RPTOR antibody  >3 publications with RRAGC/RagC and RPTOR
 RRAGB antibody  >2 publications with RRAGC/RagC and RRAGB
 NOL8 antibody  >1 publications with RRAGC/RagC and NOL8
 MLST8 antibody  >1 publications with RRAGC/RagC and MLST8

Pathways associated with anti-RRAGC/RagC antibody

 Products by Pathway  Pathway Diagram
 TOR Signaling Pathway antibodies  TOR Signaling Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram

Diseases associated with anti-RRAGC/RagC antibody

 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >1 publications with RRAGC/RagC and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with RRAGC/RagC and Disease Models, Animal

Organs/Tissues associated with anti-RRAGC/RagC antibody

 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >1 publications with RRAGC/RagC and Mouth
 Muscle Antibodies  >1 publications with RRAGC/RagC and Muscle
 Skin Antibodies  >1 publications with RRAGC/RagC and Skin
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