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Septin 2 (SEPT2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904412

Septin 2 is a filament-forming cytoskeletal GTPase. Septin 2 is required for normal organization of the actin cytoskeleton and plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus… More details

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Product Overview

Online Datasheet in PDF
Product Name
Septin 2 (SEPT2), Polyclonal Antibody
Full Product Name
Rabbit anti-Septin 2 Antibody, Affinity Purified
Product Gene Name
anti-SEPT2 antibody
Product Synonym Names
neural precursor cell expressed, developmentally down-regulated 5; DIFF6; Pnutl3; Neural precursor cell expressed developmentally down-regulated protein 5; NEDD-5; NEDD5; hNedd5; epididymis secretory sperm binding protein; septin-2; Septin-2; septin 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
42,685 Da
OMIM
601506
3D Structure
ModBase 3D Structure for Q15019
Immunogen
Between 311 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-SEPT2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-SEPT2 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-SEPT2 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-SEPT2 antibody

Detection of human Septin 2 by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-Septin 2 antibody MBS3904412 (lot MBS3904412-1) used for IP at 6 ug/mg lysate. Septin 2 was also immunoprecipitated by rabbit anti-Septin 2 antibody MBS3904411. For blotting immunoprecipitated Septin 2, MBS3904412 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 seconds.
Rabbit Anti-SEPT2 Polyclonal Antibody – Cat# MBS3904412

Western Blot (WB) of anti-SEPT2 antibody

Detection of human and mouse Septin 2 by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells. Antibodies: Affinity purified rabbit anti-Septin 2 antibody MBS3904412 (lot MBS3904412-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-SEPT2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904412

Other Notes

Small volumes of anti-SEPT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEPT2 purchase

MBS3904412 is an antibody targeting SEPT2. Also known as Rabbit anti-Septin 2 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEPT2. It may not necessarily be applicable to this product.

NCBI GI #
4758158
NCBI GeneID
4735
NCBI Accession #
NP_004395.1
UniProt Primary Accession #
Q15019
UniProt Secondary Accession #
Q14132; Q53QU3; Q8IUK9; Q96CB0; B4DGE8
UniProt Related Accession #
Q15019
GenBank Nucleotide #
NM_004404.4
NCBI Official Full Name
septin-2 isoform a
NCBI Official Synonym Full Names
septin 2
NCBI Official Symbol
SEPT2
NCBI Official Synonym Symbols
DIFF6; NEDD5; NEDD-5; Pnutl3; hNedd5
UniProt Protein Name
Septin-2
UniProt Synonym Protein Names
Neural precursor cell expressed developmentally down-regulated protein 5
Protein Family
Septin
UniProt Gene Name
SEPT2
UniProt Synonym Gene Names
DIFF6; KIAA0158; NEDD5; NEDD-5
UniProt Entry Name
SEPT2_HUMAN
NCBI Protein Information
septin-2; neural precursor cell expressed, developmentally down-regulated 5; neural precursor cell expressed developmentally down-regulated protein 5

UniProt Comments for SEPT2

SEPT2: a member of the septin family of proteins. May be involved in the process of cytokinesis. Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localized to fibrous or granular structures, depending on the growth state of the cell.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Cell development/differentiation; Cell cycle regulation; Hydrolase

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytoplasm; nucleolus; exocyst; synapse; spindle; midbody; cell cortex; nucleus; actin cytoskeleton; cleavage furrow

Molecular Function: protein binding; GTP binding; protein complex scaffold; enzyme regulator activity

Biological Process: mitosis; smoothened signaling pathway; regulation of protein localization; cell division; regulation of catalytic activity; cilium biogenesis; regulation of L-glutamate transport; neurite development
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Research Articles on SEPT2

1. SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEPT2 antibody

 Reference Product  PubMed Publications
 SEPT7 antibody  >28 publications with SEPT2 and SEPT7
 SEPT6 antibody  >22 publications with SEPT2 and SEPT6
 SEPT9 antibody  >17 publications with SEPT2 and SEPT9
 SEPT5 antibody  >8 publications with SEPT2 and SEPT5
 SEPT14 antibody  >2 publications with SEPT2 and SEPT14
 S100A4 antibody  >1 publications with SEPT2 and S100A4

Pathways associated with anti-SEPT2 antibody

 Products by Pathway  Pathway Diagram
 Anchoring Of The Basal Body To The Plasma Membrane Pathway antibodies  Anchoring Of The Basal Body To The Plasma Membrane Pathway Diagram
 Assembly Of The Primary Cilium Pathway antibodies  Assembly Of The Primary Cilium Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Organelle Biogenesis And Maintenance Pathway antibodies  Organelle Biogenesis And Maintenance Pathway Diagram

Diseases associated with anti-SEPT2 antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >2 publications with SEPT2 and Atrophy
 Nephritis Antibodies  >1 publications with SEPT2 and Nephritis
 Hemorrhage Antibodies  >1 publications with SEPT2 and Hemorrhage
 Hypertension Antibodies  >1 publications with SEPT2 and Hypertension
 Infertility, Male Antibodies  >1 publications with SEPT2 and Infertility, Male
 Edema Antibodies  >1 publications with SEPT2 and Edema
 Inflammation Antibodies  >1 publications with SEPT2 and Inflammation
 Kidney Diseases Antibodies  >1 publications with SEPT2 and Kidney Diseases

Organs/Tissues associated with anti-SEPT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with SEPT2 and Brain
 Nerve Antibodies  >8 publications with SEPT2 and Nerve
 Blood Antibodies  >7 publications with SEPT2 and Blood
 Eye Antibodies  >4 publications with SEPT2 and Eye
 Kidney Antibodies  >2 publications with SEPT2 and Kidney
 Skin Antibodies  >2 publications with SEPT2 and Skin
 Muscle Antibodies  >2 publications with SEPT2 and Muscle
 Heart Antibodies  >2 publications with SEPT2 and Heart
 Testis Antibodies  >2 publications with SEPT2 and Testis
 Liver Antibodies  >1 publications with SEPT2 and Liver
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