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RICTOR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904522

Rictor is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to… More details

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Product Overview

Online Datasheet in PDF
Product Name
Rictor, Polyclonal Antibody
Full Product Name
Rabbit anti-Rictor Antibody, Affinity Purified
Product Gene Name
anti-RICTOR antibody
Product Synonym Names
hAVO3; TORC2-specific protein AVO3; rapamycin-insensitive companion of mTOR; PIA; AVO3 homolog; AVO3; pianissimo; Rapamycin-insensitive companion of mTOR; RPTOR independent companion of MTOR complex 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
195,011 Da
OMIM
609022
3D Structure
ModBase 3D Structure for Q6R327
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-RICTOR antibody

Primary Antibodies
Applications Tested/Suitable for anti-RICTOR antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-RICTOR antibody
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-RICTOR antibody

Detection of human Rictor by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Rictor (Cat. No. MBS3904522 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB. Counterstain: IHC Hematoxylin (blue).
Rabbit Anti-RICTOR Polyclonal Antibody – Cat# MBS3904522

Immunoprecipitation (IP) of anti-RICTOR antibody

Detection of human Rictor by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-Rictor antibody MBS3904522 (lot MBS3904522-1) used for IP at 6 ug per reaction. Rictor was also immunoprecipitated by rabbit anti-Rictor antibody MBS3901030. For blotting immunoprecipitated Rictor, MBS3901030 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-RICTOR Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904522

Other Notes

Small volumes of anti-RICTOR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RICTOR purchase

MBS3904522 is an antibody targeting RICTOR. Also known as Rabbit anti-Rictor Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RICTOR. It may not necessarily be applicable to this product.

NCBI GI #
59891448
NCBI GeneID
253260
NCBI Accession #
NP_689969.2
UniProt Primary Accession #
Q6R327
UniProt Secondary Accession #
Q68DT5; Q86UB7; Q8N3A0; Q8NCM6; B2RNX0; B7ZMF7
UniProt Related Accession #
Q6R327
GenBank Nucleotide #
NM_152756.4
NCBI Official Full Name
rapamycin-insensitive companion of mTOR isoform 1
NCBI Official Synonym Full Names
RPTOR independent companion of MTOR, complex 2
NCBI Official Symbol
RICTOR
NCBI Official Synonym Symbols
PIA; AVO3; hAVO3
UniProt Protein Name
Rapamycin-insensitive companion of mTOR
UniProt Synonym Protein Names
AVO3 homolog; hAVO3
Protein Family
Rapamycin-insensitive companion
UniProt Gene Name
RICTOR
UniProt Synonym Gene Names
hAVO3
UniProt Entry Name
RICTR_HUMAN
NCBI Protein Information
rapamycin-insensitive companion of mTOR; RICTOR; pianissimo; AVO3 homolog; TORC2-specific protein AVO3

NCBI Summary for RICTOR

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

UniProt Comments for RICTOR

RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Cell cycle regulation; Ubiquitin conjugating system; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: TORC2 complex; cytosol

Molecular Function: protein binding; ribosome binding; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; TOR signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; embryonic development; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation; actin cytoskeleton reorganization; innate immune response; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway
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Research Articles on RICTOR

1. Rictor contributes to cisplatin resistance in human ovarian cancer cells by suppressing cisplatin-induced apoptosis and by activating and stabilizing Akt.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RICTOR antibody

 Reference Product  PubMed Publications
 MTOR antibody  >345 publications with RICTOR and MTOR
 RPTOR antibody  >75 publications with RICTOR and RPTOR
 MLST8 antibody  >31 publications with RICTOR and MLST8
 AKT1 antibody  >21 publications with RICTOR and AKT1
 MAPKAP1 antibody  >14 publications with RICTOR and MAPKAP1
 SGK1 antibody  >13 publications with RICTOR and SGK1
 PRR5 antibody  >8 publications with RICTOR and PRR5
 ILK antibody  >7 publications with RICTOR and ILK
 PRKCA antibody  >6 publications with RICTOR and PRKCA

Pathways associated with anti-RICTOR antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CD28 Dependent PI3K/Akt Signaling Pathway antibodies  CD28 Dependent PI3K/Akt Signaling Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram

Diseases associated with anti-RICTOR antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >27 publications with RICTOR and Insulin Resistance
 Disease Models, Animal Antibodies  >20 publications with RICTOR and Disease Models, Animal
 Brain Diseases Antibodies  >19 publications with RICTOR and Brain Diseases
 Kidney Diseases Antibodies  >17 publications with RICTOR and Kidney Diseases
 Breast Neoplasms Antibodies  >15 publications with RICTOR and Breast Neoplasms
 Inflammation Antibodies  >13 publications with RICTOR and Inflammation
 Neoplasms, Experimental Antibodies  >12 publications with RICTOR and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >12 publications with RICTOR and Adenocarcinoma
 Neoplasm Invasiveness Antibodies  >11 publications with RICTOR and Neoplasm Invasiveness
 Necrosis Antibodies  >11 publications with RICTOR and Necrosis

Organs/Tissues associated with anti-RICTOR antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >53 publications with RICTOR and Blood
 Muscle Antibodies  >44 publications with RICTOR and Muscle
 Kidney Antibodies  >27 publications with RICTOR and Kidney
 Vascular Antibodies  >23 publications with RICTOR and Vascular
 Brain Antibodies  >23 publications with RICTOR and Brain
 Liver Antibodies  >21 publications with RICTOR and Liver
 Prostate Antibodies  >21 publications with RICTOR and Prostate
 Bone Antibodies  >19 publications with RICTOR and Bone
 Lung Antibodies  >17 publications with RICTOR and Lung
 Bone Marrow Antibodies  >13 publications with RICTOR and Bone Marrow
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