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ASCT2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904542

The SLC1A5 gene encodes the sodium-dependent neutral amino acid transporter type 2 (ASCT2), a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]) [taken from NCBI… More details

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Product Overview

Online Datasheet in PDF
Product Name
ASCT2, Polyclonal Antibody
Full Product Name
Rabbit anti-ASCT2 Antibody, Affinity Purified
Product Gene Name
anti-ASCT2 antibody
Product Synonym Gene Name
SLC1A5
Product Synonym Names
R16; ASCT2; Solute carrier family 1 member 5; solute carrier family 1 (neutral amino acid transporter), member 5; sodium-dependent neutral amino acid transporter type 2; RDRC; RD114/simian type D retrovirus receptor; RD114 virus receptor; ATBO; neutral amino acid transporter B; M7VS1; M7V1; baboon M7 virus receptor; AAAT; ATB(0); neutral amino acid transporter B(0); Neutral amino acid transporter B(0); solute carrier family 1 member 5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
33,710 Da
OMIM
109190
3D Structure
ModBase 3D Structure for Q15758
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-ASCT2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-ASCT2 antibody
Immunoprecipitation (IP)
Application Notes for anti-ASCT2 antibody
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-ASCT2 antibody

Detection of human ASCT2 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-ASCT2 antibody MBS3904542 (lot MBS3904542-1) used for IP at 6 ug per reaction. ASCT2 was also immunoprecipitated by rabbit anti-ASCT2 antibody MBS3904543. For blotting immunoprecipitated ASCT2, MBS3904543 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-ASCT2 Polyclonal Antibody – Cat# MBS3904542

Other Notes

Small volumes of anti-ASCT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASCT2 purchase

MBS3904542 is an antibody targeting ASCT2. Also known as Rabbit anti-ASCT2 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ASCT2. It may not necessarily be applicable to this product.

NCBI GI #
5032093
NCBI GeneID
6510
NCBI Accession #
NP_005619.1
UniProt Primary Accession #
Q15758
UniProt Secondary Accession #
O95720; Q96RL9; Q9BWQ3; Q9UNP2; A8K9H5; B4DR77; B4DWS4; B7ZB81; D0EYG6; E9PC01
UniProt Related Accession #
Q15758
GenBank Nucleotide #
NM_005628.2
NCBI Official Full Name
neutral amino acid transporter B(0) isoform 1
NCBI Official Synonym Full Names
solute carrier family 1 (neutral amino acid transporter), member 5
NCBI Official Symbol
SLC1A5
NCBI Official Synonym Symbols
R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1
UniProt Protein Name
Neutral amino acid transporter B(0)
UniProt Synonym Protein Names
Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5
Protein Family
Neutral amino acid transporter
UniProt Gene Name
SLC1A5
UniProt Synonym Gene Names
ASCT2; M7V1; RDR; RDRC; ATB(0)
UniProt Entry Name
AAAT_HUMAN
NCBI Protein Information
neutral amino acid transporter B(0); neutral amino acid transporter B(0); ATB(0); RD114 virus receptor; baboon M7 virus receptor; solute carrier family 1 member 5; RD114/simian type D retrovirus receptor; sodium-dependent neutral amino acid transporter ty

NCBI Summary for ASCT2

The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

UniProt Comments for ASCT2

SLC1A5: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. 1 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: Golgi apparatus; membrane; integral to plasma membrane; melanosome; plasma membrane

Molecular Function: viral receptor activity; L-serine transmembrane transporter activity; protein binding; neutral amino acid transmembrane transporter activity; receptor activity; L-glutamine transmembrane transporter activity; sodium:dicarboxylate symporter activity

Biological Process: neutral amino acid transport; extracellular amino acid transport; entry of virus into host cell; amino acid transport; dicarboxylic acid transport; ion transport; glutamine transport; transmembrane transport; L-serine transport
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Research Articles on ASCT2

1. the expression of LAT1 and ASCT2 is significantly increased in human melanoma. The importance of ASCT2 expression in melanoma was confirmed by shRNA knockdown, which inhibited glutamine uptake, mTORC1 signaling and cell proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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