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DNAM-1/CD226 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904551

DNAX accessory molecule-1 (DNAM-1) is a receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell [taken from the Universal Protein Resource (UniProt)… More details

$250 / 0.01 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DNAM-1/CD226, Polyclonal Antibody
Full Product Name
Rabbit anti-DNAM-1/CD226 Antibody, Affinity Purified
Product Gene Name
anti-DNAM-1/CD226 antibody
Product Synonym Gene Name
CD226
Product Synonym Names
DNAM-1; platelet and T cell activation antigen 1; TLiSA1; T lineage-specific activation antigen 1 antigen; PTA1; adhesion glycoprotein; DNAM1; CD226 antigen; CD antigen CD226; DNAX accessory molecule 1; DNAX accessory molecule-1; CD226 antigen; CD226 molecule
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
38,614 Da
Chromosome Location
Chromosome: 18; NC_000018.9 (67530192..67624232, complement). Location: 18q22.3
OMIM
605397
3D Structure
ModBase 3D Structure for Q15762
Predicted Reactivity
Monkey
Immunogen
Between 286 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-DNAM-1/CD226 antibody

Primary Antibodies
Applications Tested/Suitable for anti-DNAM-1/CD226 antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-DNAM-1/CD226 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-DNAM-1/CD226 antibody

Detection of human DNAM-1/CD226 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-DNAM-1/CD226 antibody MBS3904551 (lot MBS3904551-1) used for IP at 6 ug per reaction. DNAM-1/CD226 was also immunoprecipitated by rabbit anti-DNAM-1/CD226 antibody BL16224. For blotting immunoprecipitated DNAM-1/CD226, MBS3904551 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-DNAM-1/CD226 Polyclonal Antibody – Cat# MBS3904551

Western Blot (WB) of anti-DNAM-1/CD226 antibody

Detection of human DNAM-1/CD226 by western blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, HEK293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-DNAM-1/CD226 antibody MBS3904551 (lot MBS3904551-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.
Rabbit Anti-DNAM-1/CD226 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904551

Other Notes

Small volumes of anti-DNAM-1/CD226 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNAM-1/CD226 purchase

MBS3904551 is an antibody targeting DNAM-1/CD226. Also known as Rabbit anti-DNAM-1/CD226 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAM-1/CD226. It may not necessarily be applicable to this product.

NCBI GI #
171460997
NCBI GeneID
10666
NCBI Accession #
NP_006557.2
UniProt Primary Accession #
Q15762
UniProt Secondary Accession #
B2R818
UniProt Related Accession #
Q15762
GenBank Nucleotide #
NM_006566.2
NCBI Official Full Name
CD226 antigen
NCBI Official Synonym Full Names
CD226 molecule
NCBI Official Symbol
CD226
NCBI Official Synonym Symbols
PTA1; DNAM1; DNAM-1; TLiSA1
UniProt Protein Name
CD226 antigen
UniProt Synonym Protein Names
DNAX accessory molecule 1
UniProt Gene Name
CD226
UniProt Synonym Gene Names
DNAM1; DNAM-1
UniProt Entry Name
CD226_HUMAN
NCBI Protein Information
CD226 antigen; adhesion glycoprotein; DNAX accessory molecule 1; DNAX accessory molecule-1; platelet and T cell activation antigen 1; T lineage-specific activation antigen 1 antigen

NCBI Summary for DNAM-1/CD226

This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008]
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UniProt Comments for DNAM-1/CD226

DNAM-1: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.3

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; external side of plasma membrane; lipid raft

Molecular Function: integrin binding; protein binding; cell adhesion molecule binding; protein kinase binding

Biological Process: regulation of immune response; positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; positive regulation of immunoglobulin mediated immune response; cytokine production; cell recognition; cell adhesion; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of mast cell activation
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Research Articles on DNAM-1/CD226

1. A CD226 three-variant haplotype is related with genetic predisposition to systemic sclerosis-related pulmonary fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DNAM-1/CD226 antibody

 Reference Product  PubMed Publications
 PVR antibody  >15 publications with DNAM-1/CD226 and PVR
 FYN antibody  >5 publications with DNAM-1/CD226 and FYN
 ITGB2 antibody  >2 publications with DNAM-1/CD226 and ITGB2

Pathways associated with anti-DNAM-1/CD226 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram

Diseases associated with anti-DNAM-1/CD226 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >50 publications with DNAM-1/CD226 and Immune System Diseases
 Neoplasms Antibodies  >45 publications with DNAM-1/CD226 and Neoplasms
 Autoimmune Diseases Antibodies  >40 publications with DNAM-1/CD226 and Autoimmune Diseases
 Nervous System Diseases Antibodies  >12 publications with DNAM-1/CD226 and Nervous System Diseases
 Inflammation Antibodies  >10 publications with DNAM-1/CD226 and Inflammation
 Cardiovascular Diseases Antibodies  >9 publications with DNAM-1/CD226 and Cardiovascular Diseases
 Diabetes Mellitus, Type 1 Antibodies  >8 publications with DNAM-1/CD226 and Diabetes Mellitus, Type 1
 Diabetes Mellitus Antibodies  >8 publications with DNAM-1/CD226 and Diabetes Mellitus
 Necrosis Antibodies  >8 publications with DNAM-1/CD226 and Necrosis
 Respiratory Tract Diseases Antibodies  >7 publications with DNAM-1/CD226 and Respiratory Tract Diseases

Organs/Tissues associated with anti-DNAM-1/CD226 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >111 publications with DNAM-1/CD226 and Blood
 Vascular Antibodies  >8 publications with DNAM-1/CD226 and Vascular
 Lymph Node Antibodies  >6 publications with DNAM-1/CD226 and Lymph Node
 Lung Antibodies  >6 publications with DNAM-1/CD226 and Lung
 Liver Antibodies  >6 publications with DNAM-1/CD226 and Liver
 Spleen Antibodies  >4 publications with DNAM-1/CD226 and Spleen
 Thymus Antibodies  >3 publications with DNAM-1/CD226 and Thymus
 Mixed Antibodies  >3 publications with DNAM-1/CD226 and Mixed
 Uterus Antibodies  >1 publications with DNAM-1/CD226 and Uterus
 Kidney Antibodies  >1 publications with DNAM-1/CD226 and Kidney
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