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P23 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904673

P23 is a molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes [taken from the Universal… More details

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Product Overview

Online Datasheet in PDF
Product Name
P23, Polyclonal Antibody
Full Product Name
Rabbit anti-P23 Antibody, Affinity Purified
Product Gene Name
anti-P23 antibody
Product Synonym Gene Name
PTGES3
Product Synonym Names
prostaglandin E synthase 3; progesterone receptor complex p23; unactive progesterone receptor, 23 kD; telomerase-binding protein p23; TEBP; P23; Hsp90 co-chaperone; cytosolic prostaglandin E2 synthase; cytosolic prostaglandin E synthase; cPGES; prostaglandin E synthase 3 (cytosolic); Prostaglandin E synthase 3; prostaglandin E synthase 3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
18,697 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (57057125..57082078, complement). Location: 12q13.3; 12
OMIM
607061
3D Structure
ModBase 3D Structure for Q15185
Predicted Reactivity
Rat, Chicken, Bovine, Orangutan
Immunogen
Between 110 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-P23 antibody

Primary Antibodies
Applications Tested/Suitable for anti-P23 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-P23 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:2000-1:10,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-P23 antibody

Detection of human P23 by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-P23 (Cat. No. MBS3904673 Lot1) used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Rabbit Anti-P23 Polyclonal Antibody – Cat# MBS3904673

Immunohistochemistry (IHC) of anti-P23 antibody

Detection of mouse P23 by immunohistochemistry. Sample: FFPE section of mouse teratoma. Antibody: Affinity purified rabbit anti-P23 (Cat. No. MBS3904673 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-P23 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3904673

Immunohistochemistry (IHC) of anti-P23 antibody

Detection of human P23 by immunohistochemistry. Sample: FFPE section of human lung cancer. Antibody: Affinity purified rabbit anti-P23 (Cat. No. MBS3904673 Lot1) used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Rabbit Anti-P23 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3904673

Immunoprecipitation (IP) of anti-P23 antibody

Detection of human P23 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-P23 antibody MBS3904673 (lot MBS3904673-1) used for IP at 6 ug per reaction. P23 was also immunoprecipitated by rabbit anti-P23 antibody BL17023. For blotting immunoprecipitated P23, MBS3904673 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-P23 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904673

Western Blot (WB) of anti-P23 antibody

Detection of human and mouse P23 by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-P23 antibody MBS3904673 (lot MBS3904673-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-P23 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904673

Other Notes

Small volumes of anti-P23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for P23 purchase

MBS3904673 is an antibody targeting P23. Also known as Rabbit anti-P23 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for P23. It may not necessarily be applicable to this product.

NCBI GI #
23308579
NCBI GeneID
10728
NCBI Accession #
NP_006592.3
UniProt Primary Accession #
Q15185
UniProt Secondary Accession #
Q8WU70; A8K7D0
UniProt Related Accession #
Q15185
GenBank Nucleotide #
NM_006601.5
NCBI Official Full Name
prostaglandin E synthase 3
NCBI Official Synonym Full Names
prostaglandin E synthase 3 (cytosolic)
NCBI Official Symbol
PTGES3
NCBI Official Synonym Symbols
P23; TEBP; cPGES
UniProt Protein Name
Prostaglandin E synthase 3
UniProt Synonym Protein Names
Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23
Protein Family
Protein
UniProt Gene Name
PTGES3
UniProt Synonym Gene Names
P23; TEBP; cPGES
UniProt Entry Name
TEBP_HUMAN
NCBI Protein Information
prostaglandin E synthase 3; Hsp90 co-chaperone; telomerase-binding protein p23; progesterone receptor complex p23; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; unactive progesterone receptor, 23 kD

UniProt Comments for P23

TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family.

Protein type: Transferase; Isomerase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3

Chromosomal Location of Human Ortholog: 12q13.3|12

Cellular Component: nucleoplasm; chromosome, telomeric region; telomerase holoenzyme complex; cytoplasm; nucleus; cytosol

Molecular Function: telomerase activity; protein binding; unfolded protein binding; prostaglandin-E synthase activity

Biological Process: RNA-dependent DNA replication; cyclooxygenase pathway; arachidonic acid metabolic process; prostaglandin biosynthetic process; signal transduction; telomere maintenance
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Research Articles on P23

1. p23 recruits PHD2 to the HSP90 machinery to facilitate HIF-1alpha hydroxylation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-P23 antibody

 Reference Product  PubMed Publications
 STIP1 antibody  >2 publications with P23 and STIP1
 DNAJB1 antibody  >2 publications with P23 and DNAJB1
 HSP90AA1 antibody  >1 publications with P23 and HSP90AA1

Pathways associated with anti-P23 antibody

 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 C20 Prostanoid Biosynthesis Pathway antibodies  C20 Prostanoid Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Regulation Of Telomerase Pathway antibodies  Regulation Of Telomerase Pathway Diagram
 Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway antibodies  Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway Diagram

Diseases associated with anti-P23 antibody

 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >1 publications with P23 and Lung Neoplasms
 Neoplasms Antibodies  >1 publications with P23 and Neoplasms
 Immune System Diseases Antibodies  >1 publications with P23 and Immune System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with P23 and Neoplasms, Experimental
 Carcinoma Antibodies  >1 publications with P23 and Carcinoma

Organs/Tissues associated with anti-P23 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with P23 and Lung
 Uterus Antibodies  >2 publications with P23 and Uterus
 Vascular Antibodies  >1 publications with P23 and Vascular
 Heart Antibodies  >1 publications with P23 and Heart
 Embryonic Tissue Antibodies  >1 publications with P23 and Embryonic Tissue
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