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p115 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904684

p115 is a general vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting… More details

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Product Overview

Online Datasheet in PDF
Product Name
p115, Polyclonal Antibody
Full Product Name
Rabbit anti-p115 Antibody, Affinity Purified
Product Gene Name
anti-p115 antibody
Product Synonym Gene Name
USO1
Product Synonym Names
USO1 vesicle docking protein homolog; general vesicular transport factor p115; Vesicle-docking protein; vesicle docking protein p115; VDP; Transcytosis-associated protein; transcytosis associated protein; TAP; P115; Protein USO1 homolog; General vesicular transport factor p115; USO1 vesicle transport factor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
109,195 Da
OMIM
603344
3D Structure
ModBase 3D Structure for O60763
Immunogen
Between 912 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-p115 antibody

Primary Antibodies
Applications Tested/Suitable for anti-p115 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-p115 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-p115 antibody

Detection of human p115 by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-p115 (Cat. No. MBS3904684 Lot1) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-p115 Polyclonal Antibody – Cat# MBS3904684

Immunoprecipitation (IP) of anti-p115 antibody

Detection of human p115 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-p115 antibody MBS3904684 (lot MBS3904684-1) used for IP at 6 ug per reaction. p115 was also immunoprecipitated by rabbit anti-p115 antibody BL17061. For blotting immunoprecipitated p115, MBS3904684 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 1 second.
Rabbit Anti-p115 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904684

Western Blot (WB) of anti-p115 antibody

Detection of human p115 by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-p115 antibody MBS3904684 (lot MBS3904684-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 1 second.
Rabbit Anti-p115 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904684

Other Notes

Small volumes of anti-p115 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for p115 purchase

MBS3904684 is an antibody targeting p115. Also known as Rabbit anti-p115 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for p115. It may not necessarily be applicable to this product.

NCBI GI #
586798161
NCBI GeneID
8615
NCBI Accession #
NP_003706.2
UniProt Primary Accession #
O60763
UniProt Secondary Accession #
Q6PK63; Q86TB8; Q8N592; B2RAQ0
UniProt Related Accession #
O60763
GenBank Nucleotide #
NM_003715.3
NCBI Official Full Name
general vesicular transport factor p115 isoform 2
NCBI Official Synonym Full Names
USO1 vesicle transport factor
NCBI Official Symbol
USO1
NCBI Official Synonym Symbols
TAP; VDP; P115
UniProt Protein Name
General vesicular transport factor p115
UniProt Synonym Protein Names
Protein USO1 homolog; Transcytosis-associated protein; TAP; Vesicle-docking protein
Protein Family
General vesicular transport factor
UniProt Gene Name
USO1
UniProt Synonym Gene Names
VDP; TAP
UniProt Entry Name
USO1_HUMAN
NCBI Protein Information
general vesicular transport factor p115

NCBI Summary for p115

The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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UniProt Comments for p115

TAP: General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. Belongs to the VDP/USO1/EDE1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Vesicle

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: Golgi membrane; Golgi apparatus; Golgi stack; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; nucleolus; cytosol

Molecular Function: protein transporter activity

Biological Process: intracellular protein transport; ER to Golgi vesicle-mediated transport; Golgi vesicle docking; vesicle fusion with Golgi apparatus; transcytosis; mitotic cell cycle
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Research Articles on p115

1. USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-p115 antibody

 Reference Product  PubMed Publications
 GORASP1 antibody  >1 publications with p115 and GORASP1

Pathways associated with anti-p115 antibody

 Products by Pathway  Pathway Diagram
 Arf1 Pathway antibodies  Arf1 Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Golgi Cisternae Pericentriolar Stack Reorganization Pathway antibodies  Golgi Cisternae Pericentriolar Stack Reorganization Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Prophase Pathway antibodies  Mitotic Prophase Pathway Diagram

Diseases associated with anti-p115 antibody

 Disease Name  Pubmed Publications
 Embryo Loss Antibodies  >1 publications with p115 and Embryo Loss
 Immune System Diseases Antibodies  >1 publications with p115 and Immune System Diseases
 Liver Diseases Antibodies  >1 publications with p115 and Liver Diseases
 Weight Loss Antibodies  >1 publications with p115 and Weight Loss

Organs/Tissues associated with anti-p115 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with p115 and Liver
 Nerve Antibodies  >2 publications with p115 and Nerve
 Thyroid Antibodies  >1 publications with p115 and Thyroid
 Blood Antibodies  >1 publications with p115 and Blood
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