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ERp5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3904691

Endoplasmic reticulum protein 5 (ERp5) may function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin [taken from the Universal Protein… More details

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Product Overview

Online Datasheet in PDF
Product Name
ERp5, Polyclonal Antibody
Full Product Name
Rabbit anti-ERp5 Antibody, Affinity Purified
Product Gene Name
anti-ERp5 antibody
Product Synonym Gene Name
PDIA6
Product Synonym Names
protein disulfide isomerase-associated 6; protein disulfide isomerase-related protein; TXNDC7; thioredoxin domain-containing protein 7; protein disulfide-isomerase A6; P5; endoplasmic reticulum protein 5; ERP5; ER protein 5; epididymis secretory sperm binding protein; thioredoxin domain containing 7 (protein disulfide isomerase); protein disulfide isomerase P5; Protein disulfide-isomerase A6; protein disulfide isomerase family A member 6
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
48,121 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (10923517..10952960, complement). Location: 2p25.1
OMIM
611099
3D Structure
ModBase 3D Structure for Q15084
Predicted Reactivity
Orangutan
Immunogen
Between 390 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-ERp5 antibody

Primary Antibodies
Applications Tested/Suitable for anti-ERp5 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-ERp5 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:2000-1:10,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-ERp5 antibody

Detection of human ERp5 by immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-ERp5 (Cat. No. MBS3904691 Lot1) used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Rabbit Anti-ERp5 Polyclonal Antibody – Cat# MBS3904691

Immunoprecipitation (IP) of anti-ERp5 antibody

Detection of human ERp5 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-ERp5 antibody MBS3904691 (lot MBS3904691-1) used for IP at 6 ug per reaction. ERp5 was also immunoprecipitated by rabbit anti-ERp5 antibody BL17102. For blotting immunoprecipitated ERp5, MBS3904691 was used at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-ERp5 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3904691

Western Blot (WB) of anti-ERp5 antibody

Detection of human ERp5 by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-ERp5 antibody MBS3904691 (lot MBS3904691-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
Rabbit Anti-ERp5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3904691

Other Notes

Small volumes of anti-ERp5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERp5 purchase

MBS3904691 is an antibody targeting ERp5. Also known as Rabbit anti-ERp5 Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ERp5. It may not necessarily be applicable to this product.

NCBI GI #
5031973
NCBI GeneID
10130
NCBI Accession #
NP_005733.1
UniProt Primary Accession #
Q15084
UniProt Secondary Accession #
Q6ZSH5; Q99778
UniProt Related Accession #
Q15084; Q53RC7
GenBank Nucleotide #
NM_005742.2
NCBI Official Full Name
protein disulfide-isomerase A6
NCBI Official Synonym Full Names
protein disulfide isomerase family A, member 6
NCBI Official Symbol
PDIA6
NCBI Official Synonym Symbols
P5; ERP5; TXNDC7
UniProt Protein Name
Protein disulfide-isomerase A6
UniProt Synonym Protein Names
Endoplasmic reticulum protein 5; ER protein 5; ERp5; Protein disulfide isomerase P5; Thioredoxin domain-containing protein 7
Protein Family
Protein
UniProt Gene Name
PDIA6
UniProt Synonym Gene Names
ERP5; P5; TXNDC7; ER protein 5; ERp5
UniProt Entry Name
PDIA6_HUMAN
NCBI Protein Information
protein disulfide-isomerase A6; ER protein 5; OTTHUMP00000115548; OTTHUMP00000200409; OTTHUMP00000200410; protein disulfide isomerase P5; endoplasmic reticulum protein 5; thioredoxin domain-containing protein 7; protein disulfide isomerase-associated 6; p

NCBI Summary for ERp5

Protein disulfide isomerases (EC 5.3.4.1), such as PDIA6, are endoplasmic reticulum (ER) resident proteins that catalyze formation, reduction, and isomerization of disulfide bonds in proteins and are thought to play a role in folding of disulfide-bonded proteins (Hayano and Kikuchi, 1995 [PubMed 7590364]).[supplied by OMIM]
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UniProt Comments for ERp5

PDIA6: May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. Belongs to the protein disulfide isomerase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 5.3.4.1; Isomerase

Chromosomal Location of Human Ortholog: 2p25.1

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen; endoplasmic reticulum; melanosome; plasma membrane; ER-Golgi intermediate compartment

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; protein folding; unfolded protein response; cell redox homeostasis; apoptotic cell clearance
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Research Articles on ERp5

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERp5 antibody

 Reference Product  PubMed Publications
 PDIA4 antibody  >5 publications with ERp5 and PDIA4
 HSPA5 antibody  >3 publications with ERp5 and HSPA5
 HSP90B1 antibody  >2 publications with ERp5 and HSP90B1

Pathways associated with anti-ERp5 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Chaperones By IRE1alpha Pathway antibodies  Activation Of Chaperones By IRE1alpha Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram

Diseases associated with anti-ERp5 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with ERp5 and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with ERp5 and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with ERp5 and Kidney Diseases
 Inflammation Antibodies  >2 publications with ERp5 and Inflammation
 Brain Diseases Antibodies  >1 publications with ERp5 and Brain Diseases
 Cardiovascular Diseases Antibodies  >1 publications with ERp5 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with ERp5 and Carcinoma, Hepatocellular
 Disease Models, Animal Antibodies  >1 publications with ERp5 and Disease Models, Animal

Organs/Tissues associated with anti-ERp5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with ERp5 and Blood
 Lung Antibodies  >4 publications with ERp5 and Lung
 Brain Antibodies  >4 publications with ERp5 and Brain
 Liver Antibodies  >3 publications with ERp5 and Liver
 Vascular Antibodies  >2 publications with ERp5 and Vascular
 Kidney Antibodies  >2 publications with ERp5 and Kidney
 Pancreas Antibodies  >2 publications with ERp5 and Pancreas
 Muscle Antibodies  >2 publications with ERp5 and Muscle
 Bone Marrow Antibodies  >2 publications with ERp5 and Bone Marrow
 Heart Antibodies  >2 publications with ERp5 and Heart
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