MAP4K6 Antibody – Rabbit

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; MSN subfamily

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: Golgi apparatus; postsynaptic membrane; axon; dendrite; cytoplasm; postsynaptic density; cell junction; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: regulation of cell-matrix adhesion; multicellular organismal development; protein amino acid autophosphorylation; dendrite morphogenesis; positive regulation of JNK cascade; negative thymic T cell selection; regulation of cell migration; protein amino acid phosphorylation; microvillus biogenesis; synaptic transmission; regulation of cell-cell adhesion; regulation of catalytic activity; actin cytoskeleton reorganization; JNK cascade; response to stress