• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

PTPN2/TCPTP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3905325

The gene PTPN2, also known as TCPTP or TCP-TP, encodes for the protein tyrosine phosphatase (PTP) family member, tyrosine-protein phosphatase non-receptor type 2. PTPs are known to be signaling molecules that regulate a variety of cellular processes including… More details

$250 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PTPN2/TCPTP, Polyclonal Antibody
Full Product Name
Rabbit anti-PTPN2/TCPTP Antibody, Affinity Purified
Product Gene Name
anti-PTPN2/TCPTP antibody
Product Synonym Gene Name
PTPN2
Product Synonym Names
TC-PTP; tyrosine-protein phosphatase non-receptor type 2; TCPTP; TCELLPTP; T-cell protein-tyrosine phosphatase; T-cell protein tyrosine phosphatase; PTPT; PTN2; Tyrosine-protein phosphatase non-receptor type 2; protein tyrosine phosphatase, non-receptor type 2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
OMIM
176887
3D Structure
ModBase 3D Structure for P17706
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-PTPN2/TCPTP antibody

Primary Antibodies
Applications Tested/Suitable for anti-PTPN2/TCPTP antibody
Western Blot (WB), Immunoprecipitation (IP)
Application Notes for anti-PTPN2/TCPTP antibody
WB: 1:500-1:2500
IP: 6ug/mg lysate

Immunoprecipitation (IP) of anti-PTPN2/TCPTP antibody

Detection of human PTPN2 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from HeLa cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-PTPN2 antibody MBS3905325 (lot MBS3905325-1) used for IP at 6 ug per reaction. PTPN2 was also immunoprecipitated by rabbit anti-PTPN2 antibody MBS3905326. For blotting immunoprecipitated PTPN2, MBS3905325 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-PTPN2/TCPTP Polyclonal Antibody – Cat# MBS3905325

Western Blot (WB) of anti-PTPN2/TCPTP antibody

Detection of human PTPN2 by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-PTPN2 antibody MBS3905325 (lot MBS3905325-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-PTPN2/TCPTP Polyclonal Antibody, Western Blot (WB) – Cat# MBS3905325

Other Notes

Small volumes of anti-PTPN2/TCPTP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPN2/TCPTP purchase

MBS3905325 is an antibody targeting PTPN2/TCPTP. Also known as Rabbit anti-PTPN2/TCPTP Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPN2/TCPTP. It may not necessarily be applicable to this product.

NCBI GeneID
5771
NCBI Accession #
NP_536348.1
UniProt Primary Accession #
P17706
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 2
UniProt Synonym Protein Names
T-cell protein-tyrosine phosphatase; TCPTP
UniProt Gene Name
PTPN2
UniProt Synonym Gene Names
PTPT; TCPTP
UniProt Entry Name
PTN2_HUMAN

UniProt Comments for PTPN2/TCPTP

PTPN2: a type 2 non-receptor phospho-tyrosine-protein phosphatase (PTP). Two alternatively spliced isoforms are differenyially expressed. Isoform A is a major PTP expressed in human tissues, while isoform B is expressed mainly in T-cells and in placenta.

Protein type: Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 18p11.3-p11.2

Cellular Component: nucleoplasm; endoplasmic reticulum; ER-Golgi intermediate compartment; plasma membrane; nucleus

Molecular Function: integrin binding; protein binding; syntaxin binding; protein tyrosine phosphatase activity; receptor tyrosine kinase binding; protein kinase binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat1 protein; cytokine and chemokine mediated signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of T cell receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of chemotaxis; glucose homeostasis; negative regulation of cell proliferation; positive regulation of gluconeogenesis; negative regulation of macrophage differentiation; negative regulation of inflammatory response; B cell differentiation; negative regulation of tyrosine phosphorylation of Stat3 protein; insulin receptor signaling pathway; negative regulation of tyrosine phosphorylation of Stat6 protein; erythrocyte differentiation; T cell differentiation
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000