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ACTR2/ARP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3905357

ARP2 actin related protein 2 homolog (ACTR2) functions as an ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization. Together with an activating nucleation-promoting factor (NPF), it mediates the formation of… More details

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Product Overview

Online Datasheet in PDF
Product Name
ACTR2/ARP2, Polyclonal Antibody
Full Product Name
Rabbit anti-ACTR2/ARP2 Antibody, Affinity Purified
Product Gene Name
anti-ACTR2/ARP2 antibody
Product Synonym Gene Name
ACTR2
Product Synonym Names
actin-like protein 2; actin-related protein 2; ARP2; Actin-related protein 2; ARP2 actin related protein 2 homolog
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
45,377 Da
OMIM
604221
3D Structure
ModBase 3D Structure for P61160
Predicted Reactivity
Rat, Zebrafish, X. laevis, X. tropicalis, Chicken, Bovine, Orangutan
Immunogen
Between 1 and 50
Conjugation
Unconjugated

Product Categories/Family for anti-ACTR2/ARP2 antibody

Primary Antibodies
Applications Tested/Suitable for anti-ACTR2/ARP2 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-ACTR2/ARP2 antibody
WB: 1:2000-1:10,000
IP: 6ug/mg lysate
IHC: 1:1000-1:5000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-ACTR2/ARP2 antibody

Detection of human ACTR2 by immunohistochemistry. Sample: FFPE section of human skin squamous cell carcinoma. Antibody: Affinity purified rabbit anti-ACTR2 (Cat. No. MBS3905357 Lot1) used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB
Rabbit Anti-ACTR2/ARP2 Polyclonal Antibody – Cat# MBS3905357

Immunoprecipitation (IP) of anti-ACTR2/ARP2 antibody

Detection of human ACTR2 by western blot of immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-ACTR2 antibody MBS3905357 (lot MBS3905357-1) used for IP at 6 ug per reaction. ACTR2 was also immunoprecipitated by rabbit anti-ACTR2 antibody MBS3905358. For blotting immunoprecipitated ACTR2, MBS3905357 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-ACTR2/ARP2 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3905357

Western Blot (WB) of anti-ACTR2/ARP2 antibody

Detection of human and mouse ACTR2 by western blot. Samples: Whole cell lysate (50 ug) from HeLa, HEK293T, Jurkat, mouse TCMK-1, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-ACTR2 antibody MBS3905357 (lot MBS3905357-1) used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-ACTR2/ARP2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS3905357

Other Notes

Small volumes of anti-ACTR2/ARP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACTR2/ARP2 purchase

MBS3905357 is an antibody targeting ACTR2/ARP2. Also known as Rabbit anti-ACTR2/ARP2 Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACTR2/ARP2. It may not necessarily be applicable to this product.

NCBI GI #
5031571
NCBI GeneID
10097
NCBI Accession #
NP_005713.1
UniProt Primary Accession #
P61160
UniProt Secondary Accession #
O15142; Q96C82; B2RCP5; D6W5F4; E9PF41
UniProt Related Accession #
P61160
GenBank Nucleotide #
NM_005722.3
NCBI Official Full Name
actin-related protein 2 isoform b
NCBI Official Synonym Full Names
ARP2 actin-related protein 2 homolog (yeast)
NCBI Official Symbol
ACTR2
NCBI Official Synonym Symbols
ARP2
UniProt Protein Name
Actin-related protein 2
UniProt Synonym Protein Names
Actin-like protein 2
UniProt Gene Name
ACTR2
UniProt Synonym Gene Names
ARP2
UniProt Entry Name
ARP2_HUMAN
NCBI Protein Information
actin-related protein 2; actin-like protein 2

NCBI Summary for ACTR2/ARP2

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for ACTR2/ARP2

ARP2: Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Belongs to the actin family. ARP2 subfamily.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding

Chromosomal Location of Human Ortholog: 2p14

Cellular Component: Arp2/3 protein complex; cell projection; focal adhesion; membrane; cytoplasm; cytosol; actin cap; actin cytoskeleton

Molecular Function: actin filament binding; structural constituent of cytoskeleton; ATP binding

Biological Process: meiotic chromosome movement towards spindle pole; axon guidance; asymmetric cell division; ephrin receptor signaling pathway; establishment and/or maintenance of cell polarity; innate immune response; cilium biogenesis; cytokinesis after meiosis; cell motility; cytoplasmic transport; spindle localization
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Research Articles on ACTR2/ARP2

1. study unveils an ARP2/3:VCA-independent function of nuclear-WASp in TH1 gene activation that is uncoupled from its cytoplasmic role in actin polymerization.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ACTR2/ARP2 antibody

 Reference Product  PubMed Publications
 ACTR3 antibody  >150 publications with ACTR2/ARP2 and ACTR3
 WASL antibody  >47 publications with ACTR2/ARP2 and WASL
 CTTN antibody  >16 publications with ACTR2/ARP2 and CTTN
 MYO1A antibody  >1 publications with ACTR2/ARP2 and MYO1A
 ARPC2 antibody  >1 publications with ACTR2/ARP2 and ARPC2
 ARPC3 antibody  >1 publications with ACTR2/ARP2 and ARPC3
 ARPC5 antibody  >1 publications with ACTR2/ARP2 and ARPC5
 ARPC1B antibody  >1 publications with ACTR2/ARP2 and ARPC1B

Pathways associated with anti-ACTR2/ARP2 antibody

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 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHB-mediated Forward Signaling Pathway antibodies  EPHB-mediated Forward Signaling Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with anti-ACTR2/ARP2 antibody

 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >3 publications with ACTR2/ARP2 and Bone Diseases
 Neoplasm Metastasis Antibodies  >2 publications with ACTR2/ARP2 and Neoplasm Metastasis
 Proteinuria Antibodies  >2 publications with ACTR2/ARP2 and Proteinuria
 Neoplasms, Experimental Antibodies  >2 publications with ACTR2/ARP2 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >2 publications with ACTR2/ARP2 and Adenocarcinoma
 Congenital Abnormalities Antibodies  >2 publications with ACTR2/ARP2 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with ACTR2/ARP2 and Abnormalities, Multiple
 Poisoning Antibodies  >1 publications with ACTR2/ARP2 and Poisoning
 Edema Antibodies  >1 publications with ACTR2/ARP2 and Edema
 Inflammation Antibodies  >1 publications with ACTR2/ARP2 and Inflammation

Organs/Tissues associated with anti-ACTR2/ARP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >46 publications with ACTR2/ARP2 and Nerve
 Blood Antibodies  >25 publications with ACTR2/ARP2 and Blood
 Muscle Antibodies  >15 publications with ACTR2/ARP2 and Muscle
 Brain Antibodies  >13 publications with ACTR2/ARP2 and Brain
 Eye Antibodies  >4 publications with ACTR2/ARP2 and Eye
 Lung Antibodies  >3 publications with ACTR2/ARP2 and Lung
 Bone Antibodies  >3 publications with ACTR2/ARP2 and Bone
 Heart Antibodies  >3 publications with ACTR2/ARP2 and Heart
 Stomach Antibodies  >2 publications with ACTR2/ARP2 and Stomach
 Bone Marrow Antibodies  >2 publications with ACTR2/ARP2 and Bone Marrow
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