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PRKRIR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3907449

P58IPK is an inhibitor of the serine/threonine protein kinase, PKR. P58IPK functions to repress eukaryotic initiation factor 2-alpha subunit (eIF-2alpha) phosphorylation by PKR. PRKRIR, also designated P52RIPK, is a P58IPK interacting protein that abrogates… More details

$250 / 0.0025 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PRKRIR, Polyclonal Antibody
Full Product Name
Rabbit anti-PRKRIR IHC Antibody, Affinity Purified
Product Gene Name
Product Synonym Gene Name
THAP12
Product Synonym Names
inhibitor of protein kinase PKR; THAP0; THAP domain-containing protein 12; THAP domain-containing protein 0; testicular tissue protein Li 133; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); PRKRIR; P58IPK-regulatory protein; P52rIPK; death-associated protein 4; DAP4; 58 kDa interferon-induced protein kinase-interacting protein; 52 kDa repressor of the inhibitor of the protein kinase; p58IPK-interacting protein; 52 kDa repressor of the inhibitor of the protein kinase; THAP domain containing 12
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
250ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
87,704 Da
OMIM
607374
3D Structure
ModBase 3D Structure for O43422
Predicted Reactivity
Rat, Horse, Rabbit, Orangutan, Monkey, Gorilla, Chimpanzee
Immunogen
Between 175 and 225
Conjugation
Unconjugated

Product Categories/Family for anti-PRKRIR antibody

Applications Tested/Suitable for anti-PRKRIR antibody
Immunohistochemistry (IHC)
Application Notes for anti-PRKRIR antibody
IHC: 1:100-1:500

Immunohistochemistry (IHC) of anti-PRKRIR antibody

Detection of human PRKRIR by immunohistochemistry. Sample: FFPE section of human skin basal cell carcinoma. Antibody: Affinity purified rabbit anti-PRKRIR (Cat. No. MBS3907449) used at a dilution of 1:250. Detection: DAB staining using anti-rabbit IHC antibody (Cat. No. MBS3900468) at a dilution of 1:100.
Rabbit Anti-PRKRIR Polyclonal Antibody – Cat# MBS3907449

Immunohistochemistry (IHC) of anti-PRKRIR antibody

Detection of mouse PRKRIR by immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-PRKRIR (Cat. No. MBS3907449) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-PRKRIR Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907449

Other Notes

Small volumes of anti-PRKRIR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRKRIR purchase

MBS3907449 is an antibody targeting PRKRIR. Also known as Rabbit anti-PRKRIR IHC Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKRIR. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
52 kDa repressor of the inhibitor of the protein kinase
NCBI Official Synonym Full Names
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
NCBI Official Symbol
PRKRIR
NCBI Official Synonym Symbols
DAP4; THAP0; THAP12; P52rIPK
UniProt Protein Name
52 kDa repressor of the inhibitor of the protein kinase
UniProt Synonym Protein Names
58 kDa interferon-induced protein kinase-interacting protein; p58IPK-interacting protein; Death-associated protein 4; THAP domain-containing protein 0
UniProt Gene Name
PRKRIR
UniProt Synonym Gene Names
DAP4; P52RIPK; THAP0; p52rIPK; p58IPK-interacting protein
UniProt Entry Name
P52K_HUMAN
NCBI Protein Information
52 kDa repressor of the inhibitor of the protein kinase; THAP domain containing 12; death-associated protein 4; p58IPK-interacting protein; inhibitor of protein kinase PKR; THAP domain-containing protein 0; 58 kDa interferon-induced protein kinase-interac

UniProt Comments for PRKRIR

PRKRIR: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, regulatory subunit; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: nucleus

Molecular Function: protein dimerization activity; DNA binding; metal ion binding

Biological Process: negative regulation of cell proliferation; response to stress; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRKRIR antibody

Organs/Tissues associated with anti-PRKRIR antibody

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