CENP-F Antibody – Rabbit Polyclonal

This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle midzone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitotis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. [provided by RefSeq, Jul 2008]

CENPF: a nuclear matrix protein that assembles onto kinetochores at late G2. Is hyperphosphorylated during mitosis and rapidly degraded after mitosis. Involved in chromosome segregation during mitosis. Interacts with retinoblastoma protein (RB), CENP-E and BUBR1. Two alternatively spliced human isoforms have been described.

Protein type: Cell cycle regulation; Transcription, coactivator/corepressor; Nuclear envelope

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: spindle pole; nuclear matrix; pronucleus; nuclear envelope; cytosol; kinetochore; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; outer kinetochore of condensed chromosome; spindle; midbody; nucleus; chromatin; chromosome, pericentric region

Molecular Function: protein C-terminus binding; dynein binding; protein binding; protein homodimerization activity; chromatin binding; transcription factor binding

Biological Process: response to drug; mitosis; muscle development; kinetochore assembly; regulation of cell cycle; chromosome segregation; cell proliferation; protein transport; cell division; mitotic cell cycle spindle assembly checkpoint; regulation of G2/M transition of mitotic cell cycle; metaphase plate congression; mitotic cell cycle; cell differentiation; G2/M transition of mitotic cell cycle; negative regulation of transcription, DNA-dependent; regulation of striated muscle development

Disease: Ciliary Dyskinesia, Primary, 31