JARID1A/RBP2 Antibody – Rabbit Polyclonal

Function: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May stimulate transcription mediated by nuclear receptors. May be involved in transcriptional regulation of Hox proteins during cell differentiation. May participate in transcriptional repression of cytokines such as CXCL12. Ref.8 Ref.9 Ref.11 Ref.12 Ref.13

Cofactor: Binds 1 Fe2+ ion per subunit

By similarity.

Subunit structure: Interacts with SUZ12; the interaction is direct

By similarity. Interacts with the viral protein-binding domain of RB1. Interacts with ESR1, MYC, MYCN and LMO2. Ref.1 Ref.6 Ref.7 Ref.8 Ref.9 Ref.14

Subcellular location: Nucleus › nucleolus. Note: Occupies promoters of genes involved in RNA metabolism and mitochondrial function

By similarity. Ref.6 Ref.9

Domain: The GSGFP motif is required for the interaction with SUZ12

By similarity.

Sequence similarities: Belongs to the JARID1 histone demethylase family.Contains 1 ARID domain.Contains 1 JmjC domain.Contains 1 JmjN domain.Contains 3 PHD-type zinc fingers.

Sequence caution: The sequence AAB28544.1 differs from that shown. Reason: Frameshift at several positions. The sequence BAE06081.1 differs from that shown. Reason: Erroneous initiation.