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PPP3CA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3907780

PPP3CA encodes the protein phosphatase 2B (PP2B) alpha catalytic subunit. PP2B, also known as calcineurin, is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. PP2B is a calcium regulated enzyme that is activated by… More details

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Product Overview

Online Datasheet in PDF
Product Name
PPP3CA, Polyclonal Antibody
Full Product Name
Rabbit anti-PPP3CA IHC Antibody, Affinity Purified
Product Gene Name
anti-PPP3CA antibody
Product Synonym Names
IECEE; protein phosphatase 3 catalytic subunit alpha isozyme; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 2B, catalytic subunit, alpha isoform; PPP2B; IECEE1; CCN1; CAM-PRP catalytic subunit; CALNA1; CALNA; CALN; calcineurin A alpha; CNA1; calmodulin-dependent calcineurin A subunit alpha isoform; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; protein phosphatase 3 catalytic subunit alpha
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
250ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
51,245 Da
OMIM
114105
3D Structure
ModBase 3D Structure for Q08209
Predicted Reactivity
Rat, X. tropicalis, Chicken, Turkey, Bovine, Dog, Horse, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, Tasmanian devil, Crab-eating macaque, African elephant, Chinese hamster, Zebra finch, Gray short-tailed opossum, Small-eared galago, Northern white-cheeked gibbon, Thirteen-lined ground squirrel
Immunogen
Between 471 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-PPP3CA antibody

Primary Antibodies
Applications Tested/Suitable for anti-PPP3CA antibody
Immunohistochemistry (IHC)
Application Notes for anti-PPP3CA antibody
IHC: 1:100-1:500

Immunohistochemistry (IHC) of anti-PPP3CA antibody

Detection of human PPP3CA by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-PPP3CA (Cat. No. MBS3907780) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-PPP3CA Polyclonal Antibody – Cat# MBS3907780

Immunohistochemistry (IHC) of anti-PPP3CA antibody

Detection of human PPP3CA by immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-PPP3CA (Cat. No. MBS3907780) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-PPP3CA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907780

Immunohistochemistry (IHC) of anti-PPP3CA antibody

Detection of mouse PPP3CA by immunohistochemistry. Sample: FFPE section of mouse colon carcinoma. Antibody: Affinity purified rabbit anti-PPP3CA (Cat. No. MBS3907780) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-PPP3CA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907780

Other Notes

Small volumes of anti-PPP3CA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPP3CA purchase

MBS3907780 is an antibody targeting PPP3CA. Also known as Rabbit anti-PPP3CA IHC Antibody, Affinity Purified. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPP3CA. It may not necessarily be applicable to this product.

NCBI GI #
6715568
NCBI GeneID
5530
NCBI Accession #
NP_000935.1
UniProt Primary Accession #
Q08209
UniProt Secondary Accession #
Q8TAW9; A1A441; A8K3B7; A8W6Z7; A8W6Z8; B5BUA2
UniProt Related Accession #
Q08209
GenBank Nucleotide #
NM_000944.4
NCBI Official Full Name
serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform 1
NCBI Official Synonym Full Names
protein phosphatase 3, catalytic subunit, alpha isozyme
NCBI Official Symbol
PPP3CA
NCBI Official Synonym Symbols
CALN; CCN1; CNA1; CALNA; PPP2B; CALNA1
UniProt Protein Name
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
UniProt Synonym Protein Names
CAM-PRP catalytic subunit; Calmodulin-dependent calcineurin A subunit alpha isoform
Protein Family
Serine/threonine-protein phosphatase
UniProt Gene Name
PPP3CA
UniProt Synonym Gene Names
CALNA; CNA
UniProt Entry Name
PP2BA_HUMAN
NCBI Protein Information
serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; CAM-PRP catalytic subunit; calcineurin A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatas

UniProt Comments for PPP3CA

PPP3CA: a calmodulin-dependent Ser/Thr phosphatase also known calcineurin A alpha. Involved in a wide range of biologic activities, acting as a Ca(2 )-dependent modifier of phosphorylation status. Dephosphorylates HSPB1. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. .

Protein type: Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: nucleoplasm; mitochondrion; cytoplasm; Z disc; cytosol; calcineurin complex; sarcolemma

Molecular Function: calmodulin binding; protein dimerization activity; protein binding; enzyme binding; calmodulin-dependent protein phosphatase activity; protein heterodimerization activity; protein serine/threonine phosphatase activity; drug binding; calcium ion binding

Biological Process: regulation of synaptic transmission; positive regulation of NFAT protein import into nucleus; T cell activation; response to amphetamine; skeletal muscle fiber development; protein amino acid dephosphorylation; negative regulation of insulin secretion; calcineurin-NFAT signaling pathway; transition between fast and slow fiber; dephosphorylation; protein import into nucleus; calcium ion transport; innate immune response; positive regulation of transcription from RNA polymerase II promoter; response to calcium ion; regulation of excitatory postsynaptic membrane potential; multicellular organismal response to stress; G1/S transition of mitotic cell cycle
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Research Articles on PPP3CA

1. Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 gene transcription.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPP3CA antibody

 Reference Product  PubMed Publications
 PPP3R1 antibody  >7 publications with PPP3CA and PPP3R1
 PPP2CB antibody  >3 publications with PPP3CA and PPP2CB
 PPP2CA antibody  >3 publications with PPP3CA and PPP2CA
 NFATC1 antibody  >2 publications with PPP3CA and NFATC1

Pathways associated with anti-PPP3CA antibody

 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
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 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram

Diseases associated with anti-PPP3CA antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with PPP3CA and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with PPP3CA and Brain Diseases
 Hypertrophy Antibodies  >3 publications with PPP3CA and Hypertrophy
 Carcinoma, Hepatocellular Antibodies  >3 publications with PPP3CA and Carcinoma, Hepatocellular
 Inflammation Antibodies  >2 publications with PPP3CA and Inflammation
 Hypertension Antibodies  >2 publications with PPP3CA and Hypertension
 Liver Diseases Antibodies  >2 publications with PPP3CA and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with PPP3CA and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with PPP3CA and Liver Neoplasms
 Edema Antibodies  >1 publications with PPP3CA and Edema

Organs/Tissues associated with anti-PPP3CA antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >10 publications with PPP3CA and Muscle
 Blood Antibodies  >6 publications with PPP3CA and Blood
 Brain Antibodies  >6 publications with PPP3CA and Brain
 Heart Antibodies  >5 publications with PPP3CA and Heart
 Vascular Antibodies  >4 publications with PPP3CA and Vascular
 Kidney Antibodies  >2 publications with PPP3CA and Kidney
 Bone Antibodies  >2 publications with PPP3CA and Bone
 Liver Antibodies  >2 publications with PPP3CA and Liver
 Eye Antibodies  >1 publications with PPP3CA and Eye
 Mammary Gland Antibodies  >1 publications with PPP3CA and Mammary Gland
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