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hSET1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3907909

hSET1B is a histone methyltransferase that associates in a complex with the non-catalytic subunits CFP1, Rbbp5, Ash2, Wdr5, and Wdr82. These five non-catalytic subunits are also part of the Set1A complex. The SET1B complex has been shown to catalyze the… More details

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Product Overview

Online Datasheet in PDF
Product Name
hSET1B, Polyclonal Antibody
Full Product Name
Rabbit anti-hSET1B IHC Antibody, Affinity Purified
Product Gene Name
anti-hSET1B antibody
Product Synonym Gene Name
SETD1B
Product Synonym Names
lysine N-methyltransferase 2G; SET domain-containing protein 1B; Set1B; histone-lysine N-methyltransferase SETD1B; hSET1B; KMT2G; Histone-lysine N-methyltransferase SETD1B; SET domain containing 1B
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
250ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
208,732 Da
OMIM
611055
3D Structure
ModBase 3D Structure for Q9UPS6
Predicted Reactivity
Bovine, Rabbit, Gorilla, Chimpanzee, Thirteen-lined ground squirrel, Northern white-cheeked gibbon
Immunogen
Between 350 and 400
Conjugation
Unconjugated

Product Categories/Family for anti-hSET1B antibody

Primary Antibodies
Applications Tested/Suitable for anti-hSET1B antibody
Immunohistochemistry (IHC)
Application Notes for anti-hSET1B antibody
IHC: 1:100-1:500

Immunohistochemistry (IHC) of anti-hSET1B antibody

Detection of human hSET1B by immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-hSET1B (Cat. No. MBS3907909) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-hSET1B Polyclonal Antibody – Cat# MBS3907909

Immunohistochemistry (IHC) of anti-hSET1B antibody

Detection of human hSET1B by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-hSET1B (Cat. No. MBS3907909) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-hSET1B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907909

Other Notes

Small volumes of anti-hSET1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for hSET1B purchase

MBS3907909 is an antibody targeting hSET1B. Also known as Rabbit anti-hSET1B IHC Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for hSET1B. It may not necessarily be applicable to this product.

NCBI GI #
210032580
NCBI GeneID
23067
NCBI Accession #
NP_055863.1
UniProt Primary Accession #
Q9UPS6
UniProt Secondary Accession #
F6MFW1
UniProt Related Accession #
Q9UPS6
GenBank Nucleotide #
NM_015048.1
NCBI Official Full Name
histone-lysine N-methyltransferase SETD1B
NCBI Official Synonym Full Names
SET domain containing 1B
NCBI Official Symbol
SETD1B
NCBI Official Synonym Symbols
KMT2G; Set1B
UniProt Protein Name
Histone-lysine N-methyltransferase SETD1B
UniProt Synonym Protein Names
Lysine N-methyltransferase 2G; SET domain-containing protein 1B; hSET1B
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
SETD1B
UniProt Synonym Gene Names
KIAA1076; KMT2G; SET1B; hSET1B
UniProt Entry Name
SET1B_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase SETD1B

NCBI Summary for hSET1B

SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]

UniProt Comments for hSET1B

SETD1B: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Protein type: Methyltransferase, protein lysine; Methyltransferase; Amino Acid Metabolism - lysine degradation; EC 2.1.1.43

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: nucleoplasm; histone methyltransferase complex; cytoplasm; nuclear speck; chromosome

Molecular Function: protein binding; histone lysine N-methyltransferase activity (H3-K4 specific); RNA binding; nucleotide binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; histone H3-K4 methylation
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Research Articles on hSET1B

1. We analyzed SETD1B expression in gastric and colorectal cancer. Loss of SETD1B was identified in 15% to 55% of the GC and CRC with respect to the microsatellite instability status. Loss of expression was more common in those with SETD1B mutations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-hSET1B antibody

 Reference Product  PubMed Publications
 SETD1A antibody  >7 publications with hSET1B and SETD1A
 CXXC1 antibody  >3 publications with hSET1B and CXXC1
 WDR82 antibody  >2 publications with hSET1B and WDR82
 ASH2L antibody  >1 publications with hSET1B and ASH2L
 RBBP5 antibody  >1 publications with hSET1B and RBBP5
 WDR5 antibody  >1 publications with hSET1B and WDR5

Pathways associated with anti-hSET1B antibody

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with anti-hSET1B antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >2 publications with hSET1B and Death
 Neoplasms Antibodies  >2 publications with hSET1B and Neoplasms
 Immune System Diseases Antibodies  >1 publications with hSET1B and Immune System Diseases
 Lymphatic Diseases Antibodies  >1 publications with hSET1B and Lymphatic Diseases
 Necrosis Antibodies  >1 publications with hSET1B and Necrosis
 Lymphoma Antibodies  >1 publications with hSET1B and Lymphoma

Organs/Tissues associated with anti-hSET1B antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with hSET1B and Kidney
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