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SPAK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3907950

STE20/SPS1-related proline-alanine rich protein kinase (SPAK) is a serine/threonine kinase that is thought to function in the cellular stress response pathway. This kinase is activated in response to hypotonic stress, leading to phosphorylation of several… More details

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Product Overview

Online Datasheet in PDF
Product Name
SPAK, Polyclonal Antibody
Full Product Name
Rabbit anti-SPAK IHC Antibody, Affinity Purified
Product Gene Name
anti-SPAK antibody
Product Synonym Gene Name
STK39
Product Synonym Names
serine/threonine-protein kinase 39; ste-20-related kinase; Ste20-like protein kinase; STE20/SPS1-related proline-alanine-rich protein kinase; STE20/SPS1 homolog; small intestine SPAK-like kinase; serine threonine kinase 39 (STE20/SPS1 homolog, yeast); proline-alanine-rich STE20-related kinase; PASK; DCHT; SPAK; STE20/SPS1-related proline-alanine-rich protein kinase; serine/threonine kinase 39
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
200ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
OMIM
607648
3D Structure
ModBase 3D Structure for Q9UEW8
Predicted Reactivity
Orangutan, Gorilla, Chimpanzee, Northern white-cheeked gibbon
Immunogen
Between 425 and 475
Conjugation
Unconjugated

Product Categories/Family for anti-SPAK antibody

Primary Antibodies
Applications Tested/Suitable for anti-SPAK antibody
Immunohistochemistry (IHC)
Application Notes for anti-SPAK antibody
IHC: 1:100-1:500

Immunohistochemistry (IHC) of anti-SPAK antibody

Detection of human SPAK by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-SPAK (Cat. No. MBS3907950) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-SPAK Polyclonal Antibody – Cat# MBS3907950

Immunohistochemistry (IHC) of anti-SPAK antibody

Detection of human SPAK by immunohistochemistry. Sample: FFPE section of human linitis plastica stomach cancer. Antibody: Affinity purified rabbit anti-SPAK (Cat. No. MBS3907950) used at a dilution of 1:250. Detection: DAB
Rabbit Anti-SPAK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907950

Immunohistochemistry (IHC) of anti-SPAK antibody

Detection of human SPAK by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-SPAK (Cat. No. MBS3907950) used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG-heavy and light chain cross-adsorbed Antibody DyLight 594 Conjugated used at a dilution of 1:100.
Rabbit Anti-SPAK Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS3907950

Other Notes

Small volumes of anti-SPAK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPAK purchase

MBS3907950 is an antibody targeting SPAK. Also known as Rabbit anti-SPAK IHC Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SPAK. It may not necessarily be applicable to this product.

NCBI GeneID
27347
NCBI Accession #
AAC72238.1
UniProt Primary Accession #
Q9UEW8
UniProt Protein Name
STE20/SPS1-related proline-alanine-rich protein kinase
UniProt Synonym Protein Names
DCHT; Serine/threonine-protein kinase 39
Protein Family
Sensor histidine kinase
UniProt Gene Name
STK39
UniProt Synonym Gene Names
SPAK; Ste-20-related kinase
UniProt Entry Name
STK39_HUMAN

UniProt Comments for SPAK

STLK3: May act as a mediator of stress-activated signals. The phosphorylated form forms a complex with WNK2. Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Protein type: Kinase, protein; Protein kinase, STE; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; FRAY subfamily

Chromosomal Location of Human Ortholog: 2q24.3

Cellular Component: cytoskeleton; basolateral plasma membrane; cytoplasm; apical plasma membrane; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; protein kinase binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-serine phosphorylation; regulation of inflammatory response; positive regulation of potassium ion transport; peptidyl-threonine phosphorylation; response to stress; protein amino acid phosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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