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Caspase-6 (CASP6) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395327

Caspase-6 (Cysteine-Requiring Aspartate Proteases) is part of a family of intracellular cysteine proteases that cleave their substrates after aspartic acid residues. These proteases play an integral role in inducing apoptosis in cells. Procaspase-6 (Mch2), a… More details

$500 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Caspase-6 (CASP6), Monoclonal Antibody
Full Product Name
Caspase-6
Product Gene Name
Product Synonym Names
Cysteine-requiring Aspartate Protease-6; Apoptotic protease Mch-2
Clonality
Monoclonal
Isotype
IgG
Clone Number
MCH2 14 1-190
Host
Mouse
Species Reactivity
Human
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purity/Purification
Protein A/G Chromatography
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Molecular Weight
33,310 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (110609785..110624629, complement). Location: 4q25
OMIM
601532
3D Structure
ModBase 3D Structure for P55212
Immunogen
Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant human capase-6 protein and mouse myeloma cells.
Positive Control
MCF-7 cell lysate

Product Categories/Family for anti-CASP6 antibody

Applications Tested/Suitable for anti-CASP6 antibody
Western Blot (WB)

Western Blot/Blotting of anti-CASP6 antibody

Western blot analysis
Mouse Anti-CASP6 Monoclonal Antibody – Cat# MBS395327

Other Notes

Small volumes of anti-CASP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASP6 purchase

MBS395327 is an antibody targeting CASP6. Also known as Caspase-6. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CASP6. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
caspase-6 isoform alpha preproprotein
NCBI Official Synonym Full Names
caspase 6, apoptosis-related cysteine peptidase
NCBI Official Symbol
CASP6
NCBI Official Synonym Symbols
MCH2
UniProt Protein Name
Caspase-6
UniProt Synonym Protein Names
Apoptotic protease Mch-2
Protein Family
UniProt Gene Name
CASP6
UniProt Synonym Gene Names
MCH2; CASP-6
UniProt Entry Name
CASP6_HUMAN
NCBI Protein Information
caspase-6; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease

NCBI Summary for CASP6

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
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UniProt Comments for CASP6

Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

Catalytic activity: Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-.

Enzyme regulation: Activation is suppressed by phosphorylation at Ser-257. Ref.6

Subunit structure: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Ref.5

Subcellular location: Cytoplasm.

Post-translational modification: Cleavages by caspase-3, caspase-8 or -10 generate the two active subunits.

Sequence similarities: Belongs to the peptidase C14A family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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