Rabbit Anti-LY96 Polyclonal Antibody – Cat# MBS395454

Western blot analysis of MD-2 in mouse spleen cell lysate with MD-2 antibody at 1 g/ml.

Lymphocyte Antigen 96/Md-2 (LY96) Antibody – Rabbit Polyclonal

Name: LY96 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS395454
Price: 720 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395454

MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Lymphocyte antigen 96/MD-2 (LY96), Polyclonal Antibody

Full Product Name

Lymphocyte antigen 96/MD-2 (IN)

Product Gene Name

anti-LY96 antibody

Product Synonym Names

ESOP-1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Provided as solution in phosphate buffered saline with 0.02% sodium azide

Purity/Purification

Antigen Immunoaffiinity Purification

Preparation and Storage

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Molecular Weight

18.4 kD

Chromosome Location

Chromosome: 8; NC_000008.10 (74903564..74941314). Location: 8q21.11

OMIM

605243

3D Structure

ModBase 3D Structure for Q9Y6Y9

Immunogen

Rabbit polyclonal MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.

Positive Control

Found in the liver and spleen, the secreted protein Lymphocyte antigen 96/MD-2 ooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria.

Product Categories/Family for anti-LY96 antibody

Polyclonal Antibody; Growth Factors & Receptors

Applications Tested/Suitable for anti-LY96 antibody

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

Other Notes

Small volumes of anti-LY96 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LY96 purchase

MBS395454 is an antibody targeting LY96. Also known as Lymphocyte antigen 96/MD-2 (IN). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LY96. It may not necessarily be applicable to this product.

NCBI GI #

307775409

NCBI GeneID

23643

NCBI Accession #

NP_001182726.1

UniProt Primary Accession #

Q9Y6Y9

UniProt Secondary Accession #

B3Y6A5

UniProt Related Accession #

Q9Y6Y9

GenBank Nucleotide #

NM_001195797.1

NCBI Official Full Name

lymphocyte antigen 96 isoform 2

NCBI Official Synonym Full Names

lymphocyte antigen 96

NCBI Official Symbol

LY96

NCBI Official Synonym Symbols

MD2; MD-2; ly-96; ESOP-1

UniProt Protein Name

Lymphocyte antigen 96

UniProt Synonym Protein Names

ESOP-1; Protein MD-2

Protein Family

Lymphocyte antigen

UniProt Gene Name

LY96

UniProt Synonym Gene Names

ESOP1; MD2; Ly-96

UniProt Entry Name

LY96_HUMAN

NCBI Protein Information

lymphocyte antigen 96; protein MD-2; myeloid differentiation protein-2

NCBI Summary for LY96

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

UniProt Comments for LY96

Function: Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both MD2 and TLR4, but not TLR4 alone, respond to LPS.

Subunit structure: Heterogeneous homopolymer formed from homodimers; disulfide-linked. Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binds to the extracellular domains of TLR2 and TLR4. Ligand binding induces interaction with TLR4 and oligomerization of the complex. Ref.7 Ref.8 Ref.9 Ref.11

Subcellular location: Secreted › extracellular space.

Post-translational modification: N-glycosylated; high-mannose. Ref.8 Ref.11

Research Articles on LY96

1. Consistently, soluble TLR4 expressed without MD2 inhibited metal- but not LPS-induced responses, opening new therapeutic perspe

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LY96 antibody

Reference Product	PubMed Publications
TLR4 antibody	>277 publications with LY96 and TLR4
CD14 antibody	>134 publications with LY96 and CD14
TLR2 antibody	>65 publications with LY96 and TLR2
MYD88 antibody	>44 publications with LY96 and MYD88
TLR1 antibody	>10 publications with LY96 and TLR1
TIRAP antibody	>7 publications with LY96 and TIRAP
CD180 antibody	>5 publications with LY96 and CD180
IRAK1 antibody	>2 publications with LY96 and IRAK1
S100A9 antibody	>1 publications with LY96 and S100A9

Pathways associated with anti-LY96 antibody

Products by Pathway	Pathway Diagram
Activated TLR4 Signalling Pathway antibodies	Activated TLR4 Signalling Pathway Diagram
Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies	Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
IKK Complex Recruitment Mediated By RIP1 Pathway antibodies	IKK Complex Recruitment Mediated By RIP1 Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
MyD88-independent Cascade Pathway antibodies	MyD88-independent Cascade Pathway Diagram
MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies	MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
NF-kappa B Signaling Pathway antibodies	NF-kappa B Signaling Pathway Diagram
Pathogenic Escherichia Coli Infection Pathway antibodies	Pathogenic Escherichia Coli Infection Pathway Diagram
Pathogenic Escherichia Coli Infection Pathway antibodies	Pathogenic Escherichia Coli Infection Pathway Diagram

Diseases associated with anti-LY96 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>88 publications with LY96 and Inflammation
Necrosis Antibodies	>53 publications with LY96 and Necrosis
Immune System Diseases Antibodies	>15 publications with LY96 and Immune System Diseases
Drug Toxicity Antibodies	>12 publications with LY96 and Drug Toxicity
Nervous System Diseases Antibodies	>9 publications with LY96 and Nervous System Diseases
Kidney Diseases Antibodies	>8 publications with LY96 and Kidney Diseases
Liver Diseases Antibodies	>8 publications with LY96 and Liver Diseases
Atherosclerosis Antibodies	>7 publications with LY96 and Atherosclerosis
Pneumonia Antibodies	>5 publications with LY96 and Pneumonia
Fibrosis Antibodies	>4 publications with LY96 and Fibrosis

Organs/Tissues associated with anti-LY96 antibody

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>18 publications with LY96 and Intestine
Liver Antibodies	>17 publications with LY96 and Liver
Brain Antibodies	>7 publications with LY96 and Brain
Uterus Antibodies	>6 publications with LY96 and Uterus
Placenta Antibodies	>2 publications with LY96 and Placenta
Adrenal Gland Antibodies	>2 publications with LY96 and Adrenal Gland
Lymph Node Antibodies	>1 publications with LY96 and Lymph Node
Pancreas Antibodies	>1 publications with LY96 and Pancreas
Thymus Antibodies	>1 publications with LY96 and Thymus