Rabbit Anti-SAMD8 Polyclonal Antibody – Cat# MBS395464

Western blot analysis using Sphingomyelin Synthase r on recombinant protein Lane A] antibody alone. Anti Rabbit secondary used at 1:25K Exposure for 30 seconds

Sphingomyelin Synthase-Related Protein 1 (SAMD8) Antibody – Rabbit Polyclonal

Name: SAMD8 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS395464
Price: 670 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395464

Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine and then onto ceramide. This also yields diacylglycerol as a side product. The reaction is catalysed by SM… More details

$670 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Sphingomyelin synthase-related protein 1 (SAMD8), Polyclonal Antibody

Full Product Name

Sphingomyelin synthase-related protein 1

Product Gene Name

anti-SAMD8 antibody

Product Synonym Names

Sphingomyelin synthase-related 1; Sterile alpha motif domain containing 8; SAMD8

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Provided as solution in phosphate buffered saline with 0.08% sodium azide

Purity/Purification

Ammonium Sulfate Precipitation

Preparation and Storage

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Molecular Weight

48321

Chromosome Location

Chromosome: 10; NC_000010.10 (76871393..76941881). Location: 10q22.2

OMIM

611575

3D Structure

ModBase 3D Structure for Q96LT4

Immunogen

Full-length recombinant sphingomyelin synthase r fusion protein

Product Categories/Family for anti-SAMD8 antibody

Polyclonal Antibody

Applications Tested/Suitable for anti-SAMD8 antibody

Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of anti-SAMD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SAMD8 purchase

MBS395464 is an antibody targeting SAMD8. Also known as Sphingomyelin synthase-related protein 1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SAMD8. It may not necessarily be applicable to this product.

NCBI GI #

292658773

NCBI GeneID

142891

NCBI Accession #

NP_001167627.1

UniProt Primary Accession #

Q96LT4

UniProt Secondary Accession #

Q5JSC5; Q5JSC8; Q66K52

UniProt Related Accession #

Q96LT4

GenBank Nucleotide #

NM_001174156.1

NCBI Official Full Name

sphingomyelin synthase-related protein 1 isoform 1

NCBI Official Synonym Full Names

sterile alpha motif domain containing 8

NCBI Official Symbol

SAMD8

NCBI Official Synonym Symbols

SMSr

UniProt Protein Name

Sphingomyelin synthase-related protein 1

UniProt Synonym Protein Names

Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8

Protein Family

Sphingomyelin synthase-related protein

UniProt Gene Name

SAMD8

UniProt Synonym Gene Names

SMSr; CPE synthase

UniProt Entry Name

SAMD8_HUMAN

NCBI Protein Information

sphingomyelin synthase-related protein 1; CPE synthase; sphingomyelin synthase related; SAM domain-containing protein 8; ceramide phosphoethanolamine synthase; sterile alpha motif domain-containing protein 8

UniProt Comments for SAMD8

Function: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Ref.8

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.8.

Domain: The SAM domain is required to retain SMAD8 in the endoplasmic reticulum.

Sequence similarities: Belongs to the sphingomyelin synthase family.Contains 1 SAM (sterile alpha motif) domain.

Sequence caution: The sequence AAH80593.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Research Articles on SAMD8

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SAMD8 antibody

Reference Product	PubMed Publications
ANKS3 antibody	>1 publications with SAMD8 and ANKS3

Pathways associated with anti-SAMD8 antibody

Products by Pathway	Pathway Diagram
Sphingomyelin Metabolism/ceramide Salvage Pathway antibodies	Sphingomyelin Metabolism/ceramide Salvage Pathway Diagram