Rabbit Anti-CRMP1 Polyclonal Antibody – Cat# MBS395495

Western blot analysis of CRMP1 in 3T3 cell lysate with CRMP1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.

Collapsin Response Mediator Protein 1 (CRMP1) Antibody – Rabbit Polyclonal

Name: CRMP1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS395495
Price: 720 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395495

Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis (1). Their continued expression in areas of high synaptic remodeling such as the… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

Collapsin response mediator protein 1 (CRMP1), Polyclonal Antibody

Full Product Name

Collapsin response mediator protein 1 (CT)

Product Gene Name

anti-CRMP1 antibody

Product Synonym Names

Collapsin response mediator protein 1 / DRP-1 / dihydropyropyrimidinase-related protein 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Provided as solution in phosphate buffered saline with 0.02% sodium azide

Purity/Purification

Antigen Immunoaffiinity Purification

Preparation and Storage

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Molecular Weight

62 kD

Chromosome Location

Chromosome: 4; NC_000004.11 (5822491..5894785, complement). Location: 4p16.1

OMIM

602462

3D Structure

ModBase 3D Structure for Q14194

Immunogen

Rabbit polyclonal CRMP1 antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human CRMP1.

Positive Control

Tissue Specificity: Brain. Located in the cytoplasm

Product Categories/Family for anti-CRMP1 antibody

Antigen Immunoaffinity Purified Polyclonal; Neuronal Signaling

Applications Tested/Suitable for anti-CRMP1 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-CRMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRMP1 purchase

MBS395495 is an antibody targeting CRMP1. Also known as Collapsin response mediator protein 1 (CT). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRMP1. It may not necessarily be applicable to this product.

NCBI GI #

14043246

NCBI GeneID

1400

NCBI Accession #

AAH07613

UniProt Primary Accession #

Q14194

UniProt Secondary Accession #

Q13024; Q4W5F1; Q96TC8; A0EJG6

UniProt Related Accession #

Q14194

NCBI Official Full Name

Collapsin response mediator protein 1

NCBI Official Synonym Full Names

collapsin response mediator protein 1

NCBI Official Symbol

CRMP1

NCBI Official Synonym Symbols

DRP1; DRP-1; CRMP-1; DPYSL1; ULIP-3

UniProt Protein Name

Dihydropyrimidinase-related protein 1

UniProt Synonym Protein Names

Collapsin response mediator protein 1; CRMP-1; Unc-33-like phosphoprotein 3

Protein Family

Dihydropyrimidinase-related protein

UniProt Gene Name

CRMP1

UniProt Synonym Gene Names

DPYSL1; ULIP3; DRP-1; CRMP-1; ULIP-3

UniProt Entry Name

DPYL1_HUMAN

NCBI Protein Information

dihydropyrimidinase-related protein 1; dihydropyrimidinase-like 1; unc-33-like phosphoprotein 3; dihydropyrimidinase related protein-1

NCBI Summary for CRMP1

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

UniProt Comments for CRMP1

Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Ref.11

Subunit structure: Homotetramer, and heterotetramer with DPYSL2, DPYSL3, DPYSL4 or DPYSL5. Interacts with PLXNA1

By similarity. Ref.10

Subcellular location: Cytoplasm. Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle. Note: Associated with centrosomes and the mitotic spindle during metaphase. Ref.11

Tissue specificity: Brain.

Sequence similarities: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.

Caution: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.

Research Articles on CRMP1

1. CRMP1 is a novel candidate protein for schizophrenia traits

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRMP1 antibody

Reference Product	PubMed Publications
SEMA3A antibody	>13 publications with CRMP1 and SEMA3A
CDK5 antibody	>6 publications with CRMP1 and CDK5
PLXNA1 antibody	>2 publications with CRMP1 and PLXNA1
PLXNA4 antibody	>1 publications with CRMP1 and PLXNA4
PLXNA3 antibody	>1 publications with CRMP1 and PLXNA3
FYN antibody	>1 publications with CRMP1 and FYN

Pathways associated with anti-CRMP1 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
CRMPs In Sema3A Signaling Pathway antibodies	CRMPs In Sema3A Signaling Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Semaphorin Interactions Pathway antibodies	Semaphorin Interactions Pathway Diagram

Diseases associated with anti-CRMP1 antibody

Disease Name	Pubmed Publications
Neoplasm Metastasis Antibodies	>4 publications with CRMP1 and Neoplasm Metastasis
Inflammation Antibodies	>2 publications with CRMP1 and Inflammation
Necrosis Antibodies	>2 publications with CRMP1 and Necrosis
Nerve Degeneration Antibodies	>1 publications with CRMP1 and Nerve Degeneration
Liver Diseases Antibodies	>1 publications with CRMP1 and Liver Diseases
Carcinoma, Hepatocellular Antibodies	>1 publications with CRMP1 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>1 publications with CRMP1 and Liver Neoplasms
Congenital Abnormalities Antibodies	>1 publications with CRMP1 and Congenital Abnormalities

Organs/Tissues associated with anti-CRMP1 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>47 publications with CRMP1 and Nerve
Brain Antibodies	>20 publications with CRMP1 and Brain
Embryonic Tissue Antibodies	>8 publications with CRMP1 and Embryonic Tissue
Lung Antibodies	>7 publications with CRMP1 and Lung
Muscle Antibodies	>5 publications with CRMP1 and Muscle
Heart Antibodies	>1 publications with CRMP1 and Heart
Intestine Antibodies	>1 publications with CRMP1 and Intestine
Testis Antibodies	>1 publications with CRMP1 and Testis
Uncharacterized Tissue Antibodies	>1 publications with CRMP1 and Uncharacterized Tissue
Eye Antibodies	>1 publications with CRMP1 and Eye