Membrane Associatedguanalyate Kinase (PDZ 4-5) (MAGI) Antibody – Sheep Polyclonal

Function: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. Ref.1

Subunit structure: Interacts with ADRB1, FZD4, FZD7, PTPRB, TGFA and VANGL2. Interacts with unidentified tyrosine phosphorylated proteins

By similarity. Interacts with BAI1, LPAR2/EDG4, GRIN2B and PTEN. In case of infection, interacts with HTLV TAX1 protein, possibly affecting the transformation ability of TAX1. Does not interact with HTLV TAX2 or TAX3 proteins. In case of infection, interacts with HPV type 16 and HPV type 18 E6 protein. Ref.1 Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.15

Subcellular location: Cell membrane; Peripheral membrane protein. Cell junction › tight junction. Nucleus

By similarity. Note: Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions

By similarity. Ref.1 Ref.8

Tissue specificity: Widely expressed. Ref.1

Post-translational modification: Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. Ref.9 Ref.15

Miscellaneous: MAGI3 PDZ domains are used to design peptide ligands that bind and inhibit PDZ domains.

Sequence similarities: Belongs to the MAGUK family.Contains 1 guanylate kinase-like domain.Contains 6 PDZ (DHR) domains.Contains 2 WW domains.

Sequence caution: The sequence BAB15479.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAB15479.1 differs from that shown. Reason: Frameshift at position 1373.