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Eotaxin (CCR3 Ligand) (CCL11) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395530

Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions1,2. Some G-protein coupled chemokine receptors are also… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
Eotaxin (CCR3 ligand) (CCL11), Polyclonal Antibody
Full Product Name
Eotaxin (CT) (CCR3 ligand)
Product Gene Name
Product Synonym Names
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative
Purity/Purification
Antigen Immunoaffiinity Purification
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Molecular Weight
10,732 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (32612687..32615199). Location: 17q21.1-q21.2
OMIM
601156
3D Structure
ModBase 3D Structure for P51671
Immunogen
Synthetic peptide corresponding to amino acids 83 to 97 of human eotaxin.
Positive Control
Recombinant Eotaxin protein
Applications Tested/Suitable for anti-CCL11 antibody
Western Blot (WB)

Western Blot/Blotting of anti-CCL11 antibody

Western blot analysis
Rabbit Anti-CCL11 Polyclonal Antibody – Cat# MBS395530

Other Notes

Small volumes of anti-CCL11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL11 purchase

MBS395530 is an antibody targeting CCL11. Also known as Eotaxin (CT) (CCR3 ligand). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
eotaxin
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 11
NCBI Official Symbol
CCL11
NCBI Official Synonym Symbols
SCYA11
UniProt Protein Name
Eotaxin
UniProt Synonym Protein Names
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Protein Family
UniProt Gene Name
CCL11
UniProt Synonym Gene Names
SCYA11
UniProt Entry Name
CCL11_HUMAN
NCBI Protein Information
eotaxin; eotaxin-1; C-C motif chemokine 11; small-inducible cytokine A11; eosinophil chemotactic protein; small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

NCBI Summary for CCL11

This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Jul 2008]
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UniProt Comments for CCL11

Function: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

Subcellular location: Secreted.

Induction: By TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.

Post-translational modification: O-linked glycan consists of a Gal-GalNAc disaccharide which is mofified with up to 2 sialic acid residues.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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