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Sphingomyelin Synthase-Related Protein 1 (SMSr) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS395540

Sphingomyelin synthases are enzymes that mediate the biosynthesis of sphingolipid headgroups. Sphingomyelin synthase 1 and 2 (SMS1 and SMS2) mediate the biosynthesis of sphingomyelin, a central sphingolipid in mammalian cells. In addition to SMS1 and SMS2, a… More details

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Product Overview

Online Datasheet in PDF
Product Name
Sphingomyelin synthase-related protein 1 (SMSr), Polyclonal Antibody
Full Product Name
Sphingomyelin synthase-related protein 1
Product Gene Name
anti-SMSr antibody
Product Synonym Names
SMSr
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Drosphila
Form/Format
Provided as solution in phosphate buffered saline with 0.08% sodium azide
Purity/Purification
Ammonium Sulfate Precipitation
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Molecular Weight
67,063 Da
Chromosome Location
Chromosome: 3L; NT_037436.3 (7367150..7374574, complement). Location: 65F7-65F9
3D Structure
ModBase 3D Structure for Q9VS60
Immunogen
Recombinant SMSr derived from Drosophila.
Positive Control
Recombinant sphingomelin synthase protein

Product Categories/Family for anti-SMSr antibody

Polyclonal Antibody; Protein Kinases
Applications Tested/Suitable for anti-SMSr antibody
Western Blot (WB)

Western Blot/Blotting of anti-SMSr antibody

Detection of 20 ng/lane recombinant SMSr using X1861P (1.25 ug/ml) and anti-rabbit HRP (1:200k) and using Pierce?s Super Signal West Femto.
Rabbit Anti-SMSr Polyclonal Antibody – Cat# MBS395540

Other Notes

Small volumes of anti-SMSr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMSr purchase

MBS395540 is an antibody targeting SMSr. Also known as Sphingomyelin synthase-related protein 1. Reactive in Drosphila. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SMSr. It may not necessarily be applicable to this product.

NCBI GI #
21356655
NCBI GeneID
38823
NCBI Accession #
NP_648114.1
UniProt Primary Accession #
Q9VS60
UniProt Secondary Accession #
Q961G5; Q9VS61
UniProt Related Accession #
Q9VS60
GenBank Nucleotide #
NM_139857.3
NCBI Official Full Name
SMSr, isoform A
NCBI Official Symbol
SMSr
NCBI Official Synonym Symbols
CG32380; CG8572; CG8576; Css3beta; DmelCG32380; dmSMSr; dSMSr
UniProt Protein Name
Sphingomyelin synthase-related 1
UniProt Synonym Protein Names
Ceramide phosphoethanolamine synthase
Protein Family
Sphingomyelin synthase-related protein
UniProt Gene Name
SMSr
UniProt Synonym Gene Names
CPE synthase
UniProt Entry Name
SMSR1_DROME
NCBI Protein Information
CG32380 gene product from transcript CG32380-RA; CG32380-PA; CG32380-PB; CPE synthase; SMSr; SMSr-PA; SMSr-PB

UniProt Comments for SMSr

Function: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Ref.6

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.6.

Domain: The SAM domain is required to retain SMSR in the endoplasmic reticulum

By similarity.

Sequence similarities: Belongs to the sphingomyelin synthase family.Contains 1 SAM (sterile alpha motif) domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SMSr antibody

 Products by Pathway  Pathway Diagram
 Sphingomyelin Metabolism Pathway antibodies  Sphingomyelin Metabolism Pathway Diagram

Diseases associated with anti-SMSr antibody

 Disease Name  Pubmed Publications
 Death Antibodies  >2 publications with SMSr and Death

Organs/Tissues associated with anti-SMSr antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with SMSr and Blood
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