SULF2 Antibody – Rabbit Polyclonal

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]

Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.

Cofactor: Binds 1 calcium ion per subunit

By similarity.

Subcellular location: Endoplasmic reticulum

By similarity. Golgi apparatus › Golgi stack

By similarity. Cell surface

By similarity. Note: Also localized on the cell surface

By similarity.

Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.

Post-translational modification: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity

By similarity.

Sequence similarities: Belongs to the sulfatase family.

Biophysicochemical propertiespH dependence:Optimum pH is 7.0-8.0.

Sequence caution: The sequence AAH20962.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA86561.2 differs from that shown. Reason: Erroneous initiation. The sequence CAB61349.1 differs from that shown. Reason: Erroneous initiation.